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TranscriptomicsRNA-seq of Glioma Neural Stem (GNS) cell line G144 after MEK inhibition in wild type (WT) and CIC (Capicua) depleted cells.
We identified genome-wide binding patterns of CIC in several different cell types and find that CIC target genes are enriched for MAPK effector genes involved in cell cycle regulation and proliferation. CIC binding to its target genes is abolished by high MAPK activity, which leads to hyperacetylati...
ORGANISM(S): Homo sapiens 
2018-05-31 | E-MTAB-6681 | biostudies-arrayexpress
GenomicsChIP-seq of CIC (Capicua) and histone marks (H3K9ac, H3K27ac and H3K4me1) in glioma neural stem cells (GNS) G144, human foetal neural stem cells (hNSC) and mouse embryonic stem cells (mESC),
We identified genome-wide binding patterns of CIC in several different cell types and find that CIC target genes are enriched for MAPK effector genes involved in cell cycle regulation and proliferation. CIC binding to its target genes is abolished by high MAPK activity, which leads to hyperacetylati...
ORGANISM(S): Homo sapiens 
2018-05-31 | E-MTAB-6682 | biostudies-arrayexpress
UnknownA perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada.
Not available
S-EPMC9596463 | biostudies-literature
ProteomicsMetabolic, Neurotoxic and Immunotoxic Effects of PFAAs and their Mixtures on the Proteome of Plasma and Head Kidney from Rainbow Trout
PFAAs (Perfluoroalkyl acids) are a class of bioaccumulative, persistent and ubiquitous aquatic contaminants. A paucity of toxicological information exists for short chain PFAAs and PFAA mixtures. In order to address these knowledge gaps, we performed a 3-week, aqueous exposure of rainbow trout to 3 ...
ORGANISM(S): Oncorhynchus Mykiss 
2024-04-23 | PXD046517 | panorama
UnknownDivergent trajectories of antiviral memory after SARS-CoV-2 infection.
Not available
S-EPMC8913789 | biostudies-literature
UnknownMaintenance darunavir/ritonavir monotherapy to prevent perinatal HIV transmission, ANRS-MIE 168 MONOGEST study.
Not available
S-EPMC10320149 | biostudies-literature
UnknownAn atlas of genetic influences on osteoporosis in humans and mice.
Not available
S-EPMC6358485 | biostudies-literature
UnknownThe Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight.
Not available
S-EPMC8393828 | biostudies-literature
UnknownA randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy.
Not available
S-EPMC2803083 | biostudies-literature
UnknownCommon, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Not available
S-EPMC8661833 | biostudies-literature
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