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GenomicsRole of Polycomb group proteins in the DNA damage response – a reassessment
We have investigated whether components of Polycomb repressive complex 1 (PRC1) are recruited to double-strand breaks (DSBs) generated by inducible expression of the AsiSI restriction enzyme in normal human fibroblasts. Using chromatin immunoprecipitation and deep sequencing (ChIP-seq), which detec...
ORGANISM(S): Homo sapiens 
2014-07-06 | E-GEOD-55605 | biostudies-arrayexpress
TranscriptomicsChIP-chip of Drosophila Polycomb group proteins Pho and dSfmbt (PhoRC) in embryos and larvae
Analysis of binding profile of the Polycomb group proteins Pho and dSfmbt (PhoRC complex) in Drosophila melanogster at two developmental stages (embryos and larvae).
ORGANISM(S): Drosophila melanogaster 
2008-11-06 | E-TABM-525 | biostudies-arrayexpress
TranscriptomicsNon-Overlapping Functions of the Polycomb group Cbx Family of Proteins in Embryonic Stem Cells
Gene expression profile in control and Cbx7 depleted (shRNA#33) mouse embryonic stem cells and embryoid bodies at day 9 4 samples, each one contains four biological replicas, except for ES-shCtr which contains 3 replicas
ORGANISM(S): Mus musculus 
2012-01-06 | E-GEOD-34191 | biostudies-arrayexpress
TranscriptomicsA Region of Human HoxD that Confers Polycomb-Group Responsiveness
Polycomb group (PcG) proteins are essential for accurate axial body patterning during embryonic development. PcG-mediated repression is conserved in metazoans and is targeted in Drosophila by Polycomb response elements (PREs). Targeting sequences in humans have not been described. While analyzing c...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-19046 | biostudies-arrayexpress
GenomicsPolycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity
We report that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to maintain embryonic stem cell (ESC) identity. In contrast to canonical PRC1, Pcgf6 acts as a positive regulator of transcription and binds predominantly to promoters bearing active chromatin marks. Pcgf6 is expres...
ORGANISM(S): Mus musculus 
2016-07-28 | E-GEOD-84905 | biostudies-arrayexpress
TranscriptomicsdKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing.
Transcription regulation involves enzyme-mediated changes in chromatin structure. Here, we describe a novel mode of histone crosstalk during gene silencing, in which histone H2A monoubiquitylation is coupled to the removal of histone H3 Lys 36 dimethylation (H3K36me2). This pathway was uncovered thr...
ORGANISM(S): Drosophila melanogaster 
2011-12-13 | E-GEOD-34390 | biostudies-arrayexpress
TranscriptomicsThe Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of histone H3 (H3). Suz12 is essential for PRC2 activity and its inactivation r...
ORGANISM(S): Mus musculus 
2011-08-11 | E-GEOD-31354 | biostudies-arrayexpress
TranscriptomicsGenome-wide Identification of Polycomb Target Genes Reveals a Functional Association of Pho with Scm in Bombyx mori
Polycomb group (PcG) proteins are involved in chromatin modifications for maintaining gene repression that play important roles in the regulation of gene expression, tumorigenesis, chromosome X-inactivation, and genomic imprinting in Drosophila melanogaster, mammals, and even plants. PcG proteins ac...
ORGANISM(S): Bombyx mori 
2012-04-17 | E-GEOD-34246 | biostudies-arrayexpress
GenomicsPolycomb Group proteins are retained at specific sites on chromatin in mitosis
Epigenetic regulation of gene expression, including by Polycomb Group (PcG) proteins, may depend on heritable chromatin states but how these states can be propagated through mitosis is unclear. Using immunofluorescence and biochemical fractionation, we find PcG proteins associated with mitotic chrom...
ORGANISM(S): Drosophila melanogaster 
2013-01-04 | E-GEOD-38166 | biostudies-arrayexpress
TranscriptomicsPCGF6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ES cells and functions in iPS reprogramming
Polycomb group (PcG) proteins comprise a large group of evolutionary conserved factors with essential roles for embryonic development and adult stem cell function. PcG proteins constitute two main multiprotein polycomb repressive complexes (PRC1 and PRC2) that operate in a hierarchical manner to sil...
ORGANISM(S): Mus musculus 
2014-09-26 | E-GEOD-56126 | biostudies-arrayexpress
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