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MetabolomicsOligofructose alleviates hyperandrogenism in polycystic ovary syndrome through gut microbiota-derived bile acids

Bile acid profiles from fecal and serum samples of letrozole-induced PCOS mouse model treated with oligofructose. Results provide insight into the bile acid changes caused by letrzole and oligofructose.

2026-02-27 | MTBLS8525 | MetaboLights
MetabolomicsAmniotic-fluid metabolomics identifies phospholipid remodeling as a metabolic signature of intrauterine exposure in pregnancies with polycystic ovary syndrome
Background: Polycystic ovary syndrome is associated with metabolic and hormonal disturbances during pregnancy, but whether these alterations are reflected in the fetal intrauterine exposure environment remains incompletely understood. This study aimed to identify polycystic ovary syndrome-related in...
2026-07-25 | MTBLS14946 | MetaboLights
MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-GC-MS analysis of follicular fluid
Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted me...
2025-04-14 | MTBLS12371 | MetaboLights
MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-GC-MS analysis of KGN cells

Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted...

2025-04-14 | MTBLS12370 | MetaboLights
MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-LC-MS analysis of granulosa cells

Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted...

2025-04-14 | MTBLS12367 | MetaboLights
MetabolomicsEffects of Yulin Tong Bu formula on modulating gut microbiota and fecal metabolite interactions in mice with polycystic ovary syndrome

BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism, ovarian dysfunction and polycystic ovarian morphology. Gut microbiota dysbiosis and metabolite are associated with PCOS clinical parameters. Yulin Tong Bu formula (YLT...

2023-02-02 | MTBLS6736 | MetaboLights
MetabolomicsMetabolomic Profiling of Follicular Fluid from Patients with Polycystic Ovary Syndrome and Hyper Response to In Vitro Fertilization Treatment
Not available
ORGANISM(S): Homo sapiens 
ST000618 | MetabolomicsWorkbench
MetabolomicsMechanisms for Insulin Resistance in Polycystic Ovary Syndrome with metformin therapy: aminoadipic acid, lysine concentrations, and enrichment (part I)
Not available
ORGANISM(S): Homo sapiens 
ST000947 | MetabolomicsWorkbench
TranscriptomicsDifferential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis
Polycystic ovary Syndrome (PCOS) is a heterogeneous endocrine disorder that shows evidence of genetic predidposition among affected individuals. We have utilized the Microarray data from granulosa cells of normal and PCOS women for network construction. Human granulosa cells were isolated from ovar...
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEOD-34526 | biostudies-arrayexpress
MetabolomicsPolycystic Ovarian Syndrome(PCOS) metabolomics
Not available
ORGANISM(S): Homo sapiens 
ST000726 | MetabolomicsWorkbench
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