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MetabolomicsMapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan
Polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid systems typically use complex protein-protein interactions to facilitate direct transfer of intermediates between these multimodular megaenzymes. In the canal-associated neurons (CANs) of Caenorhabditis elegans, PKS-1 and NR...
2021-06-22 | MTBLS2313 | MetaboLights
MetabolomicsPolyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans
Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely unexplored. We addressed this knowledge gap with the nematode ...
2025-05-06 | MTBLS8694 | MetaboLights
MetabolomicsPolyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans

Protection against pathogens is a major function of the gut microbiota. Although bacterial natural products have emerged as crucial components of host-microbiota interactions, their exact role in microbiota-mediated protection is largely unexplored. We addressed this knowledge gap with the nemato...

2025-05-27 | MTBLS8440 | MetaboLights
ProteomicsEngineering polyketide stereocenters with ketoreductase domain exchanges
Polyketide synthases (PKSs) are versatile biosynthetic megasynthases capable of producing a diverse range of natural products with many applications, including in pharmaceuticals. The stereochemical precision of PKSs makes them a powerful tool for engineering tailored, unnatural polyketides; however...
ORGANISM(S): Escherichia coli 
2025-12-01 | PXD066826 | Pride
Polyketide synthases (pks) protein engineering  kr swaps jbei 
ProteomicsEngineering an Extremely Hybrid PKS for Adipic Acid Production
Polyketide synthases (PKSs) are modular enzymes with exceptional potential as biocatalysts for producing non-native compounds. Here, we report the first PKS-based pathway for adipic acid (AA), an industrial monomer for nylon production, by engineering one of the most extensively hybridized PKS syste...
ORGANISM(S): Pseudomonas putida KT2440 
2026-09-07 | PXD069956 | Pride
Hybrid pks Polyketide synthase Adipic acid P. putida Jbei E. coli 
ProteomicsUnnatural lactam production by reprogrammed modular polyketide synthases in Pseudomonas putida
In recent years, type I polyketide synthases (PKSs) has emerged as an enticing platform for the production of novel molecules by reconstituting their modules, expanding the chemical landscape beyond the limitations of conventional metabolic engineering. This study reports a retrobiosynthesis approac...
ORGANISM(S): Pseudomonas putida KT2440 
2025-01-22 | PXD045574 | Pride
Pseudomonas putida Unatural lactam Polyketide synthases 
ProteomicsMaximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies
Type I polyketide synthases (T1PKSs) hold an enormous potential as a rational production platform for the biosynthesis of speciality chemicals. However, despite the great progress in this field, the heterologous expression of PKSs remains a major challenge. One of the first measures to improve heter...
ORGANISM(S): Corynebacterium glutamicum Escherichia coli Pseudomonas putida KT2440 
2023-09-01 | PXD042749 | Pride
Codon optimization Heterologous expression Polyketide synthases 
UnknownInsect-specific polyketide synthases (PKSs), potential PKS-nonribosomal peptide synthetase hybrids, and novel PKS clades in tropical fungi.
Not available
S-EPMC2687288 | biostudies-literature
UnknownEvolution of polyketide synthases in bacteria.
Not available
S-EPMC2290765 | biostudies-literature
UnknownEvolutionary and functional analysis of mulberry type III polyketide synthases.
Not available
S-EPMC4973071 | biostudies-literature
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