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ProteomicsIdentification of components in protein complex of influenza A virus PA protein
Influenza A virus is mainly transmitted through the respiratory route and can cause severe illness in humans. Proteins encoded by influenza A virus can interact with cellular factors and dysregulate host biological processes to facilitate viral replication and pathogenicity. The influenza viral PA p...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050585 | Pride
Spectral counting-based quantification Polymerase acidic protein (pa) Interactome Influenza a virus 
GenomicsRNA polymerase V targets transcriptional silencing components to promoters of protein-coding genes
Transcriptional gene silencing controls transposons and other repetitive elements through RNA-directed DNA methylation (RdDM) and heterochromatin formation. A key component of the Arabidopsis RdDM pathway is ARGONAUTE4 (AGO4), which associates with sizs to mediate DNA methylation. Here, we show that...
ORGANISM(S): Arabidopsis thaliana 
2012-10-17 | E-GEOD-35381 | biostudies-arrayexpress
GenomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [ChIP-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40063 | biostudies-arrayexpress
UnknownToosendanin From Melia Fructus Suppresses Influenza A Virus Infection by Altering Nuclear Localization of Viral Polymerase PA Protein.
Not available
S-EPMC6757512 | biostudies-literature
TranscriptomicsH2AZ extended acidic patch is necessary for formation specialized chromatin states in ESCs [RNA-Seq]
The H2A variant H2AZ is essential for embryonic development and for proper execution of developmental gene expression programs in embryonic stem cells (ESCs). Divergent regions in H2AZ are likely key for its functional specialization, but we know little about how these differences contribute to chro...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-40064 | biostudies-arrayexpress
UnknownPolymerase acidic subunit of H9N2 polymerase complex induces cell apoptosis by binding to PDCD 7 in A549 cells.
Not available
S-EPMC8045253 | biostudies-literature
GenomicsGenomic Study of RNA Polymerase II and III SNAPc-Bound Promoters Reveals a Gene Transcribed by both Enzymes and a Broad Use of Common Activators
SNAPc-dependent promoters are unique among cellular promoters in being very similar to each other, even though some of them recruit RNA polymerase II and other RNA polymerase III. We have examined all SNAPc-bound promoters present in the human genome. We find that there is a surprisingly small numbe...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-38303 | biostudies-arrayexpress
TranscriptomicsDifferences in cytokine production in human macrophages and in virulence in mice are attributable to the PA protein of H5N1 influenza viruses
Background. The pathogenesis of influenza A virus subtype H5N1 (hearafter, "H5N1") infection in humans is not completely understood, although hypercytokinemia is thought to play a role. We previously reported that most H5N1 viruses induce high cytokine responses in human macrophages, where...
ORGANISM(S): Homo sapiens 
2012-09-30 | E-GEOD-40711 | biostudies-arrayexpress
UnknownCystoviral polymerase complex protein P7 uses its acidic C-terminal tail to regulate the RNA-directed RNA polymerase P2.
Not available
S-EPMC4090703 | biostudies-literature
UnknownExploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA-PB1 Subunits Interaction.
Not available
S-EPMC11279468 | biostudies-literature
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