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TranscriptomicsAccumulation of inorganic polyphosphate mediates metabolic downshift and antibiotic tolerance in Mycobacterium tuberculosis
The stringent response, involving the regulatory molecules inorganic polyphosphate (poly P) and (p)ppGpp, is believed to mediate Mycobacterium tuberculosis persistence. In this study, we identified a novel exopolyphosphatase responsible for poly P hydrolysis. Using two different poly P-accumulating ...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2015-02-20 | E-GEOD-57868 | biostudies-arrayexpress
GenomicsThe yeast AMP-activated protein kinase Snf1p phosphorylates the inositol polyphosphate kinase Kcs1p
The yeast AMP-activated protein kinase Snf1p phosphorylates the inositol polyphosphate kinase Kcs1p
PRJNA1034156 | ENA
TranscriptomicsThe yeast AMP-activated protein kinase Snf1p phosphorylates the inositol polyphosphate kinase Kcs1p
The yeast Snf1p/AMP-activated kinase (AMPK) maintains energy homeostasis, controlling metabolic processes and glucose derepression in response to nutrient levels and environmental cues. Under conditions of nitrogen or glucose limitation, Snf1p regulates pseudohyphal growth, a morphological transitio...
ORGANISM(S): Saccharomyces cerevisiae 
2024-01-10 | GSE246711 | GEO
UnknownPolyphosphate Kinase Antagonizes Virulence Gene Expression in Francisella tularensis.
Not available
S-EPMC5763045 | biostudies-literature
UnknownPolyphosphate kinase deletion increases laboratory productivity in cyanobacteria.
Not available
S-EPMC10879606 | biostudies-literature
MetabolomicsBiosynthesis of polyamine–polyphosphate granules for colitis alleviation

Natural polyamines, such as spermidine and spermine, exert strong anti-inflammatory effects, but their therapeutic benefits are limited by rapid absorption in the small intestine, resulting in low colonic availability. In this study, engineered Citrobacter freundii overexpressing ppk1 (CPP) coul...

2026-01-07 | MTBLS13621 | MetaboLights
TranscriptomicsHuman inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity
Messenger (m)RNA export from the nucleus is essential for eukaryotic gene expression. Here, we identify a transcript-selective nuclear export mechanism affecting certain human transcripts, enriched for functions in genome duplication and repair, controlled by inositol polyphosphate multikinase (IPMK...
ORGANISM(S): Homo sapiens 
2013-09-27 | E-GEOD-49658 | biostudies-arrayexpress
UnknownCrystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis.
Not available
S-EPMC1369109 | biostudies-literature
UnknownInositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.
Not available
S-EPMC1200306 | biostudies-literature
UnknownPolyphosphate-kinase-1 dependent polyphosphate hyperaccumulation for acclimation to nutrient loss in the cyanobacterium, Synechocystis sp. PCC 6803.
Not available
S-EPMC11322815 | biostudies-literature
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