Polyunsaturated fatty acid

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Unknown (3867)
Genomics (246)
Transcriptomics (232)
Metabolomics (86)
Proteomics (56)
Clinical (6)
Models (3)
Methylation profiling (2)
Other (2)
Genomic (1)

Organisms

Mus musculus (90)
Homo sapiens (71)
Rattus norvegicus (24)
Salmo salar (13)
Sus scrofa (8)
Caenorhabditis elegans (6)
Saccharomyces cerevisiae (5)
Arabidopsis thaliana (5)
Bos taurus (5)
Daphnia magna (3)
Candida albicans (3)
Papio anubis (2)
Oryctolagus cuniculus (2)
Gallus gallus (2)
Drosophila melanogaster (2)
Danio rerio (2)
Schizosaccharomyces pombe (2)
Chelon labrosus (1)
Salvia hispanica (1)
Gadus morhua (1)
Lobosphaera incisa (1)
Ettlia oleoabundans (1)
Neochloris aquatica (1)
Streptococcus pneumoniae D39 (1)
Marchantia polymorpha (1)
Mesocricetus auratus (1)
Brassica napus (1)
Pseudomonas aeruginosa (1)
Staphylococcus aureus (1)
Zea mays (1)

Organisms

Mus musculus (61)
Homo sapiens (41)
Rattus norvegicus (12)
Caenorhabditis elegans (5)
Sus scrofa (3)
Bos taurus (3)
Aurantiochytrium mangrovei (2)
Nannochloropsis oceanica (2)
Cyprinus carpio (2)
Drosophila melanogaster (2)
Danio rerio (2)
Arabidopsis thaliana (2)
Saccharomyces cerevisiae (2)
Nannochloropsis limnetica (1)
Nannochloropsis sp. C95 (1)
Schizochytrium sp. CCTCC M209059 (1)
Microchloropsis gaditana (1)
Ettlia oleoabundans (1)
Stenotrophomonas nitritireducens (1)
Photobacterium profundum (1)
Streptococcus pneumoniae D39 (1)
Aurantiochytrium sp. T66 (1)
Neochloris aquatica (1)
Nannochloropsis oculata (1)
Thraustochytrium sp. 26185 (1)
Plukenetia volubilis (1)
Parietichytrium sp. I65-24A (1)
Nannochloropsis granulata CCMP529 (1)
Aurantiochytrium sp. KH105 (1)
Mortierella alpina (1)

Repository

ENA (235)
geo (146)
biostudies-arrayexpress (100)
MetaboLights (84)
pride (38)
iProX (8)
MassIVE (7)
BioModels (3)
EGA (2)
jPOST (2)
MetabolomicsWorkbench (2)
dbGaP (1)
PAXDB (1)

Tissue

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Blood (1)
Adipose tissue (1)
Blood (1)
Blood plasma (1)
Blood platelet (1)
Blood serum (1)
Breast epithelium (1)
Colon epithelial cell (1)
Early embryonic cell (1)
Embryo (1)
Erythrocyte (1)
Extracellular vesicle (1)
HEK-293T cell (1)
Intestinal epithelial cell (1)
Muscle (1)
Neuron associated cell (1)
Peritoneal macrophage (1)
Platelet (1)
Platelet activation (1)
Protoplast (1)
Retinal pigment epithelial cell (1)

Disease

Colorectal Neoplasms (4)
Disease free (3)
Apparently healthy (2)
Breast cancer (2)
Colon cancer (2)
Malignant neoplasm of ovary (2)
Type 2 diabetes mellitus (2)
Colorectal carcinoma (1)
Colonic adenocarcinoma (1)
Normal (1)
Compliance (1)
Adenomatous Polyps (1)
Barth syndrome (1)
Hereditary elliptocytosis (1)
Infertility (1)
Metabolic dysfunction-associated steatohepatitis (1)
Neuronal ceroid lipofuscinosis 3 (1)

Technology Type

Mass spectrometry (64)
Mass Spectrometry (40)
Shotgun proteomics (21)
Mass spectrometry assay (18)
Bottom-up proteomics (9)
Data-dependent acquisition (6)
SWATH MS (4)
Data-independent acquisition (3)
NMR spectroscopy (2)
EI (2)
Top-down proteomics (2)
Affinity purification coupled with mass spectrometry proteomics (1)
SRM/MRM (1)

Instrument Platform

Liquid Chromatography MS - positive - reverse phase (27)
Liquid Chromatography MS - negative - reverse phase (27)
Liquid Chromatography MS - negative - hilic (8)
Liquid Chromatography MS - positive - reverse-phase (6)
Liquid Chromatography MS - negative - reverse-phase (6)
Liquid Chromatography MS - positive - hilic (6)
Gas Chromatography MS - positive (5)
Liquid Chromatography MS - (5)
Liquid Chromatography MS - alternating - reverse-phase (5)
Liquid Chromatography MS - alternating - hilic (5)
Q Exactive (4)
Liquid Chromatography MS - alternating - reverse phase (4)
Liquid Chromatography MS - positive - HILIC (4)
Liquid Chromatography MS - negative - HILIC (3)
Illumina HiSeq 1500 (2)
Illumina HiSeq 2500 (2)
Orbitrap Exploris 480 (2)
TripleTOF 6600, AB Sciex (2)
Liquid Chromatography MS - Positive (LC-MS (Positive)) (2)
Affymetrix GeneChip(R) HT Scanner (1)
Illumina Genome Analyzer II (1)
Affymetrix Fluidics Station 400 (1)
Illumina NovaSeq 6000 (1)
Illumina HiSeq 3000 (1)
Illumina HiSeq 4000 (1)
6470A Triple Quadrupole LC/MS (1)
QTRAP 6500+ (1)
Sciex 5600+ TripleTOF (1)
Wates I-Class/XEVO-G2 XS QTOF (1)
LTQ FT ULTRA (Thermo Scientific) (1)

Publication Date

2026 (46)
2025 (45)
2022 (30)
2020 (25)
2018 (23)
2019 (22)
2016 (22)
2024 (21)
2023 (20)
2011 (17)
2012 (16)
2013 (15)
2021 (15)
2010 (12)
2017 (10)
2014 (10)
2008 (10)
2009 (9)
2015 (8)
2007 (7)
2006 (2)
2005 (1)

UNIPROT ID/AC

8030.ENSSSAP00000000285 (1)
8030.ENSSSAP00000000573 (1)
8030.ENSSSAP00000000871 (1)
8030.ENSSSAP00000001022 (1)
8030.ENSSSAP00000001240 (1)
8030.ENSSSAP00000001511 (1)
8030.ENSSSAP00000001597 (1)
8030.ENSSSAP00000002059 (1)
8030.ENSSSAP00000002148 (1)
8030.ENSSSAP00000002643 (1)
8030.ENSSSAP00000002671 (1)
8030.ENSSSAP00000002680 (1)
8030.ENSSSAP00000002684 (1)
8030.ENSSSAP00000002690 (1)
8030.ENSSSAP00000002813 (1)
8030.ENSSSAP00000003421 (1)
8030.ENSSSAP00000003619 (1)
8030.ENSSSAP00000004639 (1)
8030.ENSSSAP00000004862 (1)
8030.ENSSSAP00000005034 (1)
8030.ENSSSAP00000005246 (1)
8030.ENSSSAP00000005299 (1)
8030.ENSSSAP00000005382 (1)
8030.ENSSSAP00000005521 (1)
8030.ENSSSAP00000005622 (1)
8030.ENSSSAP00000006110 (1)
8030.ENSSSAP00000006568 (1)
8030.ENSSSAP00000006671 (1)
8030.ENSSSAP00000006691 (1)
8030.ENSSSAP00000006723 (1)

CHEBI ID

CHEBI:15428 (14)
CHEBI:15891 (14)
CHEBI:30769 (13)
CHEBI:16196 (13)
CHEBI:15354 (13)
CHEBI:16335 (12)
CHEBI:15756 (12)
CHEBI:17562 (11)
CHEBI:28875 (11)
CHEBI:16704 (11)
CHEBI:28716 (11)
CHEBI:17351 (11)
CHEBI:28300 (10)
CHEBI:16708 (10)
CHEBI:28842 (10)
CHEBI:6650 (10)
CHEBI:17568 (10)
CHEBI:15843 (10)
CHEBI:16027 (10)
CHEBI:17596 (10)
CHEBI:17368 (10)
CHEBI:30805 (9)
CHEBI:18237 (9)
CHEBI:16040 (9)
CHEBI:17724 (9)
CHEBI:16750 (9)
CHEBI:25017 (9)
CHEBI:15741 (9)
CHEBI:28044 (9)
CHEBI:16865 (9)

Metabolite Name

Choline (11)
Cytidine (11)
Diethanolamine (9)
Nicotinamide (9)
Valine (8)
Betaine (8)
Thymine (8)
L-Histidine (8)
Oleamide (8)
Cytosine (8)
Linoleic acid (8)
Guanosine (8)
Creatinine (8)
Creatine (8)
L-Phenylalanine (8)
Hypoxanthine (8)
L-Alanine (7)
Uracil (7)
L-Proline (7)
L-Threonine (7)
Taurine (7)
Adenosine (7)
Spermidine (7)
N-Acetylputrescine (7)
Histamine (7)
Guanine (7)
Testosterone (7)
Xanthine (7)
Uridine (7)
L-Valine (7)

First Public Date

2026 (39)
2014 (30)
2025 (28)
2024 (23)
2022 (18)
2018 (17)
2023 (15)
2020 (14)
2019 (14)
2017 (10)
2013 (10)
2021 (9)
2016 (4)
2015 (4)

Modelling Approach

Ordinary differential equation model (2)
Constraint-based model (1)

Study status

Completed (3)
Withdrawn (1)
Not provided (1)
Recruiting (1)

Lab affiliation

1. Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China. 2. Shandong Energy Institute, Qingdao 266101, China. 3. Qingdao New Energy Shandong Laboratory, Qingdao 266101, China. (2)
Proteomics Unit, IMIBIC, Reina Sofía University Hospital, University of Córdoba, Córdoba, Spain (2)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (2)
1 Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 2 University of Chinese Academy of Sciences, Beijing 100049, China (1)
1. Gavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA 2. Department of Physiology and Biophysics, School of Medicine, University of California Irvine, CA (1)
Associate Staff Director of Research Center for Microbiome & Human Healt Cleveland Clinic (1)
Center for Tumor Biology and Immunology (ZTI), Philipps University, Hans-Meerwein-Strasse 3, 35043 Marburg, Germany (1)
Clinic and Polyclinic for Pediatric and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany (1)
Columbia University Department of Biological Sciences and Department of Chemistry (1)
DIVAS, University of Milan (1)
DZNE - German Center for Neurodegenerative Diseases Munich, Neuroproteomics, Feodor-Lynen Str. 17, D-81377 Munich, Germany (1)
Department of Biomedical Sciences, University of Copenhagen, Denmark (1)
Department of Chemistry, Columbia University, New York, NY 10027 (1)
Department of Chemistry, Columbia University, New York, NY 10027, USA. (1)
Department of Molecular Neurosciences, Center for Brain 1099 Research, Medical University of Vienna, Vienna, Austria (1)
Department of Ophthalmology, University of California, Irvine, CA 92697 (1)
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA (1)
Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea (1)
Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Germany (1)
Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany and Clinic for Dermatology, St. Josef Hospital Bochum, University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany (1)
Instituto de Investigaciones Sanitarias de Santiago de Compostela (1)
Keck MS & Proteomics Resource Yale School of Medicine (1)
Key Laboratory of Protein and Peptide Pharmaceuticals & Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China (1)
Laboratory of Biotechnology of Reproduction, Institute for Animal Science and Technology (ICTA), Universitat Politècnica de València, 46022 Valencia, Spain (1)
Lehrstuhl für Ernährungsphysiologie, Technische Universität München (TUM), Gregor-Mendel-Str. 2, 85354 Freising, Germany; Phone: +498161-71-2385 (1)
Medizinisches Proteom-Center, Medical Faculty, Ruhr-University Bochum, 44801 Bochum, Germany (1)
Proteomics Core Facility, University of Gothenburg (1)
Proteomics and Immunodiagnostic Lab at Porto Conte Ricerche Srl, Alghero (SS), Italy. (1)
Proteomics facility manager (1)
Sylvester Comprehensive Cancer Center, Miami, FL, US. Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, US. (1)

Keyword

Eicosapentaenoic acid free fatty acid (1)
Fish Oils (1)
Fatty Acids, Omega-3 (1)
Randomised Controlled Trial (1)
Omega-3 fatty acid (1)
Fish oil (1)
Gut microbiota (1)
Nutrition (1)
Tumor microenvironment (1)
Eicosapentaenoic Acid (1)
Polyp (1)
Eicosapentaenoic acid ethyl ester (1)
Liver Metastases (1)
Colorectal Neoplasm (1)
Immune response (1)

IsPrivate

False (3)

Classification

bacteria (3)
fungi (2)

Study type

Transcription profiling by array (86)
RNA-seq of coding RNA (8)
Interventional (5)
Unknown experiment type (1)
Human - High-throughput sequencing (1)
Transcription profiling by RT-PCR (1)
ChIP-seq (1)
Methylation profiling by array (1)
Observational (1)

Release Date

2022 (464)
2023 (430)
2021 (380)
2020 (372)
2025 (339)
2024 (313)
2019 (296)
2018 (239)
2017 (193)
2016 (185)
2015 (158)
2014 (133)
2013 (105)
2012 (75)
2011 (72)
2026 (55)
2010 (51)
2009 (30)
2008 (29)
2007 (18)
2006 (9)
2005 (7)
2004 (4)
2003 (3)
2001 (3)
2000 (2)
2002 (1)
1997 (1)

Location

United States (2)
Denmark (1)
Italy (1)
United Kingdom (1)
France (1)

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Intermittent fasting mobilizes polyunsaturated fatty acid eicosapentaenoic acid inducing ferroptosis to suppress hepatocellular carcinoma progression

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a leading cause of hepatocellular carcinoma (HCC), prompting ongoing efforts to understand its mechanisms and develop targeted therapies. Although dietary interventions such as fasting influence tumor growth, the underlying mole...

2026-08-28 | MTBLS15484 | MetaboLights

Omega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus

Background

Omega-3 polyunsaturated fatty acids (PUFAs) are known to protect against type 1 diabetes mellitus (T1DM), but how they act through the gut-islet axis is not fully understood. This study explored how Omega-3 PUFA-influenced gut microbiota and their metabolites help protect pancrea...

2026-06-13 | MTBLS13006 | MetaboLights

Omega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus

Background

2026-06-13 | MTBLS13174 | MetaboLights

Omega-3 polyunsaturated fatty acids modulate gut microbiota-derived 18β-glycyrrhetinic acid to alleviate type 1 diabetes mellitus_fecal_Omega-3 PUFAs

Background

2026-06-13 | MTBLS13979 | MetaboLights

The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid-Serum raw data

Not available

ORGANISM(S): Mus musculus

ST000452 | MetabolomicsWorkbench

The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid-Heart raw data

Not available

ORGANISM(S): Mus musculus

ST000451 | MetabolomicsWorkbench

SCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism

BACKGROUND: Myocardial infarction (MI), one of the leading causes of mortality worldwide, remains a clinical challenge due to limitations in current therapeutic strategies. The cardiac vascular network, as the fundamental architecture sustaining myocardial function, delivers oxygen and nutrients ...

2025-09-18 | MTBLS13005 | MetaboLights

SCUBE3 enhances post-myocardial infarction angiogenesis by promoting endothelial fatty acid metabolism.

2025-09-18 | MTBLS13004 | MetaboLights

MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer. Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those containing the polyunsaturated fatty acid arachidonic acid (AA), is central in driving ferroptosis. Here, we reveal that ...

2023-09-06 | MTBLS8280 | MetaboLights

Sarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights

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4502 Results

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INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

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