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TranscriptomicsBiological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen® cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up t...
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10166 | biostudies-arrayexpress
GenomicsAssembly of methylated LSD1 and CHD1 drives AR-dependent transcription and translocation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-12-07 | E-GEOD-64530 | biostudies-arrayexpress
GenomicsAssembly of methylated LSD1 and CHD1 drives AR-dependent transcription and translocation [ChIP-Seq]
The aim of the study is to identify AR target gens in LNCaP cells 5 samples corresponding to LSD1 K114me2 or CHD1 genome-binding in DHT-treated and control LNCaP cells. 6 samples corresponding to LSD1 K114me2 or CHD1 genome-binding in LNCaP cells knocked-down for LSD1 or CHD1 and treated with DHT.
ORGANISM(S): Homo sapiens 
2015-12-07 | E-GEOD-64528 | biostudies-arrayexpress
GenomicsChIPseq examination of EAP-1 binding across generations of spr-5(by101) mutant worms
How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans Histone H3 lysine 4 dimethyl (H3K4me2) demethylase spr-5 leads to inherited accumulation of the euchromatic H3K4me2 mark and progressive decline in fertility. Here we identifie...
ORGANISM(S): Caenorhabditis elegans 
2014-04-08 | E-GEOD-52102 | biostudies-arrayexpress
TranscriptomicsAn RNASeq normal tissue atlas for mouse and rat
The function of a gene is closely connected to its expression specificity across tissues and cell types. RNA-Seq is a powerful quantitative tool to explore genome wide expression. The aim of the present study is to provide a comprehensive RNA-Seq dataset across the same 13 tissues for mouse and rat,...
ORGANISM(S): Rattus norvegicus 
2017-10-25 | E-MTAB-6081 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Chronic Lymphocytic Leukemia patients with and without t(14;19) samples, and normal mature B cells
Characterize the transcriptomes of CLL with and without t(14;19)
ORGANISM(S): Homo sapiens 
2026-07-14 | E-MTAB-15004 | biostudies-arrayexpress
TranscriptomicsMAGE-seq E.coli infA amplicon high-throughput genotyping data, mutants from Kelsic et al. Cell Systems, 2016
MAGE-seq amplicon data from the paper RNA structural determinants of optimal codons revealed by MAGE-seq in Cell Systems 2016 by Kelsic, Chung, Cohen, Park, Wang & Kishony. Data contains read counts for PCR amplicons of the Escherichia coli gene infA: 1) Single codon mutants tiling along the entire ...
ORGANISM(S): Escherichia coli 
2016-10-01 | E-MTAB-4020 | biostudies-arrayexpress
TranscriptomicsRNA-seq of isogenic panel of HAP1 cell lines knockout for chromatin remodeling encoding genes
Epigenetic dysregulation is a major cancer hallmark. Notably, deleterious mutations in genes encoding subunits of SWI/SNF (SWItch Sucrose Non-Fermentable), a major chromatin remodeling complex, occur in approximately 20% of human solid tumors. SWI/SNF mutations have been linked to poor patient outco...
ORGANISM(S): Homo sapiens 
2025-10-20 | E-MTAB-15673 | biostudies-arrayexpress
TranscriptomicsGene Bionetworks that Regulate Ovarian Primordial Follicle Assembly
Primordial follicle assembly is the process by which ovarian primordial follicles are formed. During follicle assembly oocyte nests break down and a layer of pre-granulosa cells surrounds individual oocytes to form primordial follicles. The pool of primordial follicles formed is the source of oocy...
ORGANISM(S): Rattus norvegicus 
2013-01-15 | E-GEOD-43464 | biostudies-arrayexpress
TranscriptomicsRNA-SEQ analysis of single cells extracted from the metanephric mesenchyme of Embryonic day 11.5 (E11.5) Crym-EGFP transgenic mice.
We used micro-dissection with FACS sorting techniques to isolate single cells from the metanephric mesenchyme of the E11.5 developing kidney. A subset of these single cell populations is analysed individually via Fluidigm single cell analysis. This analysis will determine the transcriptional profi...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-59129 | biostudies-arrayexpress
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