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ProteomicsHydrogen-deuterium exchange points to interactions at the helicase - topoisomerase interface in reverse gyrase that play a role in positive DNA supercoiling
Reverse gyrase is a DNA topoisomerase that catalyzes positive DNA supercoiling in an ATP-dependent reaction. The enzyme consists of a helicase and a topoisomerase domain. The isolated helicase-like domain is a DNA-stimulated ATPase, and the isolated topoisomerase domain can relax supercoiled DNA. Fo...
ORGANISM(S): Thermotoga maritima 
2026-08-24 | PXD074413 | Pride
Topoisomerase Helicase Reverse gyrase Conformational changes Positive dna supercoiling 
TranscriptomicsSaccharomyces cerevisiae cells: control vs positive supercoiling accumulation
This SuperSeries is composed of the following subset Series: GSE18240: Saccharomyces cerevisiae cells: control vs positive supercoiling accumulation after 0, 30 and 120 min GSE18241: S. cerevisiae cells: control vs positive supercoiling accumulation in absence of telomere silencing after 0 and 120 m...
ORGANISM(S): Saccharomyces cerevisiae 
2009-12-01 | E-GEOD-18242 | biostudies-arrayexpress
GenomicsHigh-resolution, genome-wide mapping of positive supercoiling in chromosomes [ecChIP]
High-resolution, genome-wide mapping of positive supercoiling in chromosomes [ecChIP]
PRJNA640689 | ENA
GenomicsHigh-resolution, genome-wide mapping of positive supercoiling in chromosomes [yChIP]
High-resolution, genome-wide mapping of positive supercoiling in chromosomes [yChIP]
PRJNA640691 | ENA
GenomicsHigh-resolution, genome-wide mapping of positive supercoiling in chromosomes [RNA-seq]
High-resolution, genome-wide mapping of positive supercoiling in chromosomes [RNA-seq]
PRJNA640690 | ENA
GenomicsHigh-resolution, genome-wide mapping of positive supercoiling in chromosomes [RNA-Seq 2]
High-resolution, genome-wide mapping of positive supercoiling in chromosomes [RNA-Seq 2]
PRJNA689471 | ENA
UnknownPositive supercoiling favors transcription elongation through lac repressor-mediated DNA loops.
Not available
S-EPMC8934669 | biostudies-literature
UnknownCrystal structures of Thermotoga maritima reverse gyrase: inferences for the mechanism of positive DNA supercoiling.
Not available
S-EPMC3553957 | biostudies-literature
GenomicsHigh-resolution, genome-wide mapping of positive supercoiling in chromosomes [ecChIP]
Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three- dimensional organization of chromosomes. However, there are currently no methods to directly interrogate or map positive supercoils, so their distribution in genomes remains unknown. Here, we describe a metho...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2021-06-25 | GSE152880 | GEO
GenomicsHigh-resolution, genome-wide mapping of positive supercoiling in chromosomes [yChIP]
Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three-dimensional organization of chromosomes. However, there are currently no methods to directly interrogate or map positive supercoils, so their distribution in genomes remains unknown. Here, we describe a method...
ORGANISM(S): Saccharomyces cerevisiae 
2021-06-25 | GSE152881 | GEO
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