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TranscriptomicsLRH1 silencing inhibits human colon cancer growth.
This study was undertaken to better determine the function of LRH-1 (NR5A2) in the colorectal cancers (CRC) through inducible shRNA-mediated knockdown within well-established CRC cell line Caco-2 Our work is the first to demonstrate that silencing of LRH-1 in established human CRC cell lines impairs...
ORGANISM(S): Homo sapiens 
2015-02-24 | E-GEOD-64695 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of response of Buchnera aphidicola to depletion of essential amino acids combined with an increase in sucrose in the diet of its aphid host
The aim of this work was to analyze the transcriptomic response of Buchnera aphidicola when the aphid host is submitted to depletion in essential amino acids (EAA). This treatment was combined with an increase in sucrose concentration to influence the bacterial growth rate. In this experiment, the d...
ORGANISM(S): Buchnera aphidicola 
2006-04-03 | E-TABM-85 | biostudies-arrayexpress
OtherMixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency.
Data from ProteomeXchange, PXD ID: PXD002150. File: 14july14_saha_b_65.mzml. Published as part of Antiviral Res. 2015 Sep 3. pii: S0166-3542(15)00213-2 . From the Abstract: {{i}} ... We therefore utilized a combined analysis of effects of SAHA on the host transcriptome and proteome to dissect its m...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310023592 | GPMDB
Resource Reanalysis 
TranscriptomicsMethylation changes in pre MAPKi treatment and post MAPKi resistance Melanomas
Melanoma resistance to MAPK- or T cell checkpoint-targeted therapies represents a major clinical challenge, and treatment failures of MAPK-targeted therapies due to acquired resistance often require salvage immunotherapies. We show that genomic analysis of acquired resistance to MAPK inhibitors reve...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-65183 | biostudies-arrayexpress
TranscriptomicsExpression changes in pre MAPKi treatment and post MAPKi resistance Melanomas
Melanoma resistance to MAPK- or T cell checkpoint-targeted therapies represents a major clinical challenge, and treatment failures of MAPK-targeted therapies due to acquired resistance often require salvage immunotherapies. We show that genomic analysis of acquired resistance to MAPK inhibitors reve...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-65184 | biostudies-arrayexpress
UnknownShared Transcriptomic Signatures in Perilesional and Contralesional Cortex.
Not available
S-EPMC12889578 | biostudies-literature
TranscriptomicsRNAseq changes in pre MAPKi treatment and post MAPKi resistance Melanomas
Melanoma resistance to MAPK- or T cell checkpoint-targeted therapies represents a major clinical challenge, and treatment failures of MAPK-targeted therapies due to acquired resistance often require salvage immunotherapies. We show that genomic analysis of acquired resistance to MAPK inhibitors reve...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-65185 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from hypothyroid mice pups produced from dams given 6-propyl-2-thiouracil (PTU) in their drinking water
Pregnant dams were treated with 0.1% or 0.04% 6-propyl-2-thiouracil (PTU) in drinking water continuously from day 13 post conception until weaning to produce hypothyroid pups. livers were collected from vehicle and 0.1% PTU treated pups at post-natal day (PND) 15 and mRNA from these was subjected to...
ORGANISM(S): Mus musculus 
2007-05-03 | E-MEXP-1091 | biostudies-arrayexpress
TranscriptomicsMethylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.
Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describ...
ORGANISM(S): Homo sapiens 
2014-09-13 | E-GEOD-61380 | biostudies-arrayexpress
TranscriptomicsGene expression in helped versus helpless CD8 T cells
CD4+ ‘helper’ T cells (TH) are pivotal for the generation and maintenance of CD8+ T cell responses. ‘Helped’ CD8+ T cells receive signals during priming that prevent the induction of the pro-apoptotic molecule TRAIL during reactivation, thereby enabling robust secondary expansion. Conversely, ‘helpl...
ORGANISM(S): Mus musculus 
2011-11-26 | E-GEOD-33862 | biostudies-arrayexpress
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