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MetabolomicsUntargetted lipidomics dataset: LC-MS analysis in two postmortem brain areas of healthy individuals and schizophrenia patients.

Schizophrenia is a common mental illness. It is a complex disorder with many symptoms and cognitive impairments. Despite extensive study, the molecular mechanisms of this disease are still unknown. Present time studies on the lipid composition of the human brain are extremely fragmented. Of the p...

2024-06-04 | MTBLS8955 | MetaboLights
ProteomicsProteomic profiling of postmortem prefrontal cortex tissue of suicide completers
A total of 36 postmortem brain samples (23 suicide completers, 13 control sudden death) were collected. We evaluated the proteome profile in the prefrontal cortex (Brodmann area 9, 10) with TMT-based quantification using LC-MS/MS. Several bioinformatics tools were used to elucidate biological mechan...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD029845 | Pride
Suicide Proteomics Tandem mass tag Postmortem brain Lc-ms/ms 
TranscriptomicsDNA methylation in postmortem brain samples from autism cases and controls
We used the Illumina 450KMethylation BeadChip to measure DNA methylation at 485,512 loci across the genome for 40 postmortem brain samples. The purpose of our study was to identify differentially methylated regions (DMRs) associated with autism. Samples included 16 temporal cortex brain tissue sampl...
ORGANISM(S): Homo sapiens 
2013-12-12 | E-GEOD-53162 | biostudies-arrayexpress
TranscriptomicsExpression mRNA data from human postmortem putamen samples measured using the NanoString nCounter platform
Background: Molecular adaptations in the striatum mediated by dopamine (DA) denervation or Levodopa (L-dopa) treatment have been implicated with the motor deficits found in Parkinson’s disease (PD). Alterations in glutamatergic neurotransmission and anti-oxidant mechanisms are reported to play imp...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77666 | biostudies-arrayexpress
TranscriptomicsProfiling Transcriptomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders
Analysis of transcriptiomic alternations related with alcohol use disorders (AUDs). The hypothesis is that chronic alcohol consumption might alter genome-wide gene expression patterns. The results suggest that differential gene expression in the prefrontal cortex is implicated in neuroadaptations to...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-49376 | biostudies-arrayexpress
GenomicsPostmortem human microbiome
Postmortem human microbiome Raw sequence reads
PRJNA925138 | ENA
TranscriptomicsExpression miRNA data from human postmortem putamen samples measured using the NanoString nCounter platform
Background: Molecular adaptations in the striatum mediated by dopamine (DA) denervation or Levodopa (L-dopa) treatment have been implicated with the motor deficits found in Parkinsonâ??s disease (PD). Alterations in glutamatergic neurotransmission and anti-oxidant mechanisms are reported to play imp...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77667 | biostudies-arrayexpress
GenomicsHuman Postmortem Microbiome - Ecology of 188 Cases
Human Postmortem Microbiome - Ecology of 188 Cases
PRJEB22642 | ENA
TranscriptomicsCardiac mesenchymal progenitors from postmortem cardiac tissue retained cellular characterization
Background and Objective: Currently, the cells for transplantation were derived from either autologous or allogeneic tissue. The former has a drawback that the quality of donor cells could depend on the patient’s condition, and the quantity could also be limited. To solve these problems, we investig...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-50221 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human postmortem skeletal muscle vs. surgically obtained skeletal muscle
Standard Affymetrix procedure, RNA from frozen tissue
ORGANISM(S): Homo sapiens 
2007-09-28 | E-GEOD-595 | biostudies-arrayexpress
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