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MetabolomicsFOXK1 and FOXK2 Promote Cardiomyocyte Proliferation and Heart Regeneration
Promoting the proliferation of endogenous cardiomyocytes represents a promising strategy for treating cardiac injuries. Identifying key factors that regulate cardiomyocyte proliferation can advance the development of novel therapies for heart regeneration. Here we identify that FOXK1 and FOXK2 act a...
2025-02-13 | MTBLS12191 | MetaboLights
TranscriptomicsDifferential gene expression in mouse skNAC knockout heart at E11.5
Targeted deletion of skNAC in mice resulted in early embryonic lethality with cardiac defects. In order to investigate the molecular mechanism of the cardiac defect, we designed the microarray comparing gene expression of the mutant E11.5 heart to wild type E11.5 heart. Keywords: genetic modificat...
ORGANISM(S): Mus musculus 
2010-11-19 | E-GEOD-5841 | biostudies-arrayexpress
GenomicsEpigenome profiling of neonatal heart regeneration
Epigenome profiling of neonatal heart regeneration
PRJNA510092 | ENA
GenomicsTranscriptome profiling of neonatal heart regeneration
Transcriptome profiling of neonatal heart regeneration
PRJNA510091 | ENA
UnknownRedox-dependent purine degradation triggers postnatal loss of cardiac regeneration potential.
Not available
S-EPMC11664147 | biostudies-literature
TranscriptomicsFunctionally conserved non-coding regulators of cardiomyocyte proliferation and regeneration in mouse and human
The adult mammalian heart has little regenerative capacity after myocardial infarction (MI) while neonatal mouse heart regenerates without scarring or dysfunction. However, the underlying pathways are poorly defined. We sought to derive insights into the pathways regulating neonatal development of t...
ORGANISM(S): Mus musculus 
2018-02-02 | E-MTAB-6272 | biostudies-arrayexpress
TranscriptomicsCardiac gene expression profiling of neonatal Salvador mutant mice
In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cr...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-44103 | biostudies-arrayexpress
GenomicsThe PIDDosome controls cardiomyocyte polyploidization during postnatal heart development
The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development
PRJNA1153931 | ENA
GenomicsSingle cell ATAC-seq of neonatal heart regeneration
Single cell ATAC-seq of neonatal heart regeneration
PRJNA642813 | ENA
GenomicsSingle cell RNA-seq of neonatal heart regeneration
Single cell RNA-seq of neonatal heart regeneration
PRJNA642814 | ENA
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