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GenomicsDe novo DNA methylation by DNA Methyltransferase 3a controls early effector CD8+ T cell fate decisions following activation
DNMT3a is a de novo DNA methyltransferase expressed robustly after T cell activation that regulates plasticity of CD4+ T cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8+ T cell effector and memory fate decisions. While effector function of DNMT3a knockout T cel...
ORGANISM(S): Mus musculus 
2016-08-20 | E-GEOD-85823 | biostudies-arrayexpress
TranscriptomicsExpression analysis of a full SlrV locus 1 knockout in Haemophilus influenzae strain PittII
Investigation of whole genome gene expression differences between a full (four-gene) SlrV locus 1 deletion compared to the WT PittII strain. Removal of the four SlrV genes (aka macrophage survival factors : ?msf) results in a competetive defect with the WT strain in in vitro biofilms and in the oti...
ORGANISM(S): Haemophilus influenzae PittII 
2015-06-23 | E-GEOD-70172 | biostudies-arrayexpress
UnknownPathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease
Not available
S-SCDT-10_1038-S44321-024-00172-5 | biostudies-other
UnknownMetabolic shift underlies recovery in reversible infantile respiratory chain deficiency
Not available
S-SCDT-EMBOJ-2020-105364-T | biostudies-other
TranscriptomicsExpression analysis of a full Lsr locus knockout in Haemophilus influenzae strain CZ4126/02
Investigation of whole genome gene expression differences in a full (nine-gene) Lsr locus knockout strain compared to the wild-type strain (CZ4126/02). This Lsr mutant is unable to import the autoinducer-2 (AI-2) quorum sensing molecule nor mediate any potential LsrR-based transcriptional regulation...
ORGANISM(S): Haemophilus influenzae 
2012-10-19 | E-GEOD-41690 | biostudies-arrayexpress
TranscriptomicsExpression analysis of a full Lsr locus knockout on the luxS knockout background of Haemophilus influenzae strain CZ4126/02
Investigation of whole genome gene expression differences between a full (nine-gene) Lsr locus deletion and a luxS deletion strain (double knock-out) compared to a luxS isogenic mutant strain (each derived from the CZ4126/02 parent strain). Both strains are unable to produce the autoinducer-2 (AI-2)...
ORGANISM(S): Haemophilus influenzae 
2014-05-06 | E-GEOD-57288 | biostudies-arrayexpress
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
UnknownPrognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
Not available
S-EPMC6254006 | biostudies-literature
UnknownImpact of postoperative acute kidney injury in patients undergoing major gastrointestinal surgery on 1-year survival and renal outcomes: a national multicentre cohort study.
Not available
S-EPMC8759520 | biostudies-literature
UnknownChallenges of one-year longitudinal follow-up of a prospective, observational cohort study using an anonymised database: recommendations for trainee research collaboratives.
Not available
S-EPMC6909648 | biostudies-literature
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