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TranscriptomicsExploring the scope of TOR/PKA co-regulation in MDN
To identify genes co-regulated by TOR and PKA during growth in MDN BCY1, bcy1 deletion, TPK, and tpk1-3 deletion strains were grown in MDN with and without rapamycin treatment. Different combinations of these samples were examined.
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-3160 | biostudies-arrayexpress
TranscriptomicsIdentification of new target genes of TOR during growth in MDN
To identify novel targets of TOR when prototrophic strain S288c is grown in MDN media. Arrays compare growth in MDN with and without addition of rapamycin. For comparison, growth in YPD versus MDN as well as SCD versus MDN were examined as well.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-30 | E-GEOD-3157 | biostudies-arrayexpress
TranscriptomicsComparing global transcriptional changes that resulted from loss of Ypk1 or Ypk2 activity
To identify genes regulated by the AGC kinases Ypk1 and Ypk2 Experiment is designed to identify genes regulated by the kinases Ypk1 and Ypk2. These are functionally redundant AGC kinases such that yeast cells can grow in the presence of either one but the absence of both is lethal. We used a chemi...
ORGANISM(S): Saccharomyces cerevisiae 
2011-10-28 | E-GEOD-33185 | biostudies-arrayexpress
TranscriptomicsSmall molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation. Reprogramming of the ER proteostasis environment through genetic activation of the Unfolded Protein Response (UP...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-GEOD-84636 | biostudies-arrayexpress
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