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ProteomicsSelf-priming of Plk1 binding to BubR1 ensures accurate mitotic progression
Plk1 is a key mitotic kinase that localizes to distinct subcellular structures to promote accurate mitotic progression. Plk1 recruitment depends on direct interaction between polo-box domain (PBD) on Plk1 and PBD binding motif (PBD BM) on the interactors. However, recent study showed that PBD BM alo...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096264 | MassIVE
ProteomicsA chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase
Serine-threonine phosphatases have been challenging to study because of the lack of specific inhibitors. Their catalytic domains are druggable, but these are shared or very similar between individual phosphatase complexes, precluding their specific inhibition. Instead, phosphatase complexes achieve ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-06 | PXD056390 | Pride
Phosphoproteomics Phosphatase Phosphorylation Pp2a-b56 
ProteomicsDeterminants of site-specific dephosphorylation by PP2A-B56
The tumor suppressor PP2A is a major cellular protein phosphatase that regulates numerous cellular processes through the formation of holoenzymes containing distinct regulatory B-subunits. However, the determinants of differential substrate dephosphorylation by PP2A are poorly understood. Here, we d...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-08-28 | MSV000084245 | MassIVE
UnknownA dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
Not available
S-EPMC7108865 | biostudies-literature
UnknownCrystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.
Not available
S-EPMC4930772 | biostudies-literature
ProteomicsA highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis
The shugoshin proteins are universal protectors of centromeric cohesin during mitosis and meiosis. The binding of human hSgo1 to the PP2A-B56 phosphatase through a coiled coil (CC) region mediates cohesion protection during mitosis. Here we undertook a structure function analysis of the PP2A-B56-hSg...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-04 | MSV000087003 | MassIVE
UnknownExpanding the PP2A Interactome by Defining a B56-Specific SLiM.
Not available
S-EPMC5180209 | biostudies-literature
ProteomicsA complex of BRCA2 and PP2A-B56 is required for homologous recombination-mediated DNA repair
Mutations in the tumour suppressor BRCA2 are associated with predisposition to breast and ovarian cancers. BRCA2 has a central role in genome integrity by facilitating the repair of toxic DNA double-strand breaks (DSBs) by homologous recombination. BRCA2 acts by promoting RAD51 nucleofilament format...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-26 | MSV000087884 | MassIVE
UnknownDivision of labour between PP2A-B56 isoforms at the centromere and kinetochore.
Not available
S-EPMC6398977 | biostudies-literature
ProteomicsCell killing by iHAP and DT-061 is not through PP2A-B56 activation
PP2A is an abundant ser/thr protein phosphatase that act as a tumor suppressor by antagonizing multiple oncogenic kinases. For this reason, compounds able to activate PP2A holoenzymes are attractive anticancer agents. DT-061 and iHAP are phenothiazine derivatives that have recently been claimed to a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-06-11 | MSV000087616 | MassIVE
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