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GenomicsEBF2 determines and maintains brown adipocyte identity
We compared PPARg binding sites in BAT and eWAT to identify regulatory elements that contribute to BAT identity and to find an important factor that bind those elements. To this end, we performed PPARg ChIP-seq in both tissues and called each tissue-spsecific binding sites. PPARg ChIP-seq in BAT and...
ORGANISM(S): Mus musculus 
2013-03-18 | E-GEOD-43763 | biostudies-arrayexpress
GenomicsGenome-wide occupancy of PPARG and RXRA after treatment with PPARG inverse agonist
Genome-wide occupancy of PPARG and RXRA after treatment with PPARG inverse agonist
PRJNA1270055 | ENA
TranscriptomicsDisruption of PPARg signaling results in mouse prostatic intraepithelial neoplasia (mPIN) involving active autophagy
Peroxisome proliferator-activated receptor-gamma (PPARg) regulates the interface between cellular lipid metabolism, redox status and organelle differentiation. Following conditional prostatic epithelial knockout of PPARg in mice we observed focal hyperplasia of the epithelium which developed to mous...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-13867 | biostudies-arrayexpress
TranscriptomicsPlacental PPARg-Regulated Genes
Robust identification of placental PPARg target genes via mutliple PPARg-dependence criteria. Integration of differential expression data from Pparg-null, Rxra-null, Med1-nul and Ncoa6-null placentas and from WT and Pparg-null Trophoblast stem cells (TSC) differentiated for 2 or 4 days in the presen...
ORGANISM(S): Mus musculus 
2012-07-09 | E-GEOD-39233 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adipose tissue from Pparg animals
Identifying gene expression changes in adipose tissue of lipodystrophic Pparg targeted mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old Pparg males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChipâ?¢ arrays, one mouse p...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9131 | biostudies-arrayexpress
GenomicsGene perturbation after PPARG expression in basal UMUC6 cells
Gene perturbation after PPARG expression in basal UMUC6 cells
PRJNA592888 | ENA
TranscriptomicsTranscription profiling of human monocytes from patients with dominant negative mutations in PPARg and rosiglitazone treated cells to investigate PPARg regulated gene expression in human dendritic cells
In order to gain insights into how PPARg regulates different facets of dendritic cell (DC) differentiation, we sought to identify PPARg regulated genes and gene networks in monocyte-derived dendritic cells using global gene expression profiling. We employed an exogenous ligand activation approach us...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8658 | biostudies-arrayexpress
GenomicsPPARG regulated genes in the day 14 ovine conceptus
PPARG ChIP seq analysis was conducted to determine genes bound by and potentially regulated by PPARG in the developing ovine conceptus. Determination of gene regulation by prostaglandins through PPARG helps to improve our understanding of early pregnancy events and provides a basis for strategies to...
ORGANISM(S): Ovis aries 
2014-07-03 | E-GEOD-59011 | biostudies-arrayexpress
GenomicsGenome-wide profiling of PPAR?:RXR and RNA polymerase II
Genome-wide profiling of PPAR?:RXR and RNA polymerase II reveals temporal activation of distinct metabolic pathways in RXR dimer composition during adipogenesis. Chromatin immunoprecipitation combined with deep sequencing was performed to generate genome-wide maps of peroxisome prolifelator-activat...
ORGANISM(S): Mus musculus 
2008-12-10 | E-GEOD-13511 | biostudies-arrayexpress
GenomicsCannabidiol ameliorates mitochondrial disease via PPARg activation
Cannabidiol ameliorates mitochondrial disease via PPARg activation
PRJNA1105908 | ENA
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