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TranscriptomicsDisruption of PPARg signaling results in mouse prostatic intraepithelial neoplasia (mPIN) involving active autophagy
Peroxisome proliferator-activated receptor-gamma (PPARg) regulates the interface between cellular lipid metabolism, redox status and organelle differentiation. Following conditional prostatic epithelial knockout of PPARg in mice we observed focal hyperplasia of the epithelium which developed to mous...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-13867 | biostudies-arrayexpress
GenomicsNodal/Smad2 signaling sustains developmental pausing by repressing Pparg -mediated lipid metabolism [RNA-Seq]
Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg -mediated lipid metabolism [RNA-Seq]
PRJNA1297148 | ENA
GenomicsNodal/Smad2 signaling sustains developmental pausing by repressing Pparg -mediated lipid metabolism [ATAC-Seq]
Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg -mediated lipid metabolism [ATAC-Seq]
PRJNA1292134 | ENA
GenomicsNodal/Smad2 signaling sustains developmental pausing by repressing Pparg -mediated lipid metabolism [ATAC-seq]
Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg -mediated lipid metabolism [ATAC-seq]
PRJNA1293325 | ENA
TranscriptomicsPPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived macrophages
Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 3 mice per group was is...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25123 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived alternatively activated macrophages and immature dendritic cells (iDCs)
Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 4 mice per group was is...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25125 | biostudies-arrayexpress
UnknownPparg signaling controls bladder cancer subtype and immune exclusion.
Not available
S-EPMC8545976 | biostudies-literature
GenomicsCell-intrinsic tumorigenic functions of PPARg in bladder urothelial carcinoma [RNA-seq]
Cell-intrinsic tumorigenic functions of PPARg in bladder urothelial carcinoma [RNA-seq]
PRJNA702003 | ENA
TranscriptomicsTranscription profiling of human freshly isolated PPARg and RARa ligand treated dendritic cells
Our data indicated that activation of the PPARg nuclear receptor induces a retinoid response in human dendritic cells. In order to assess the contribution of retinoid signaling to the PPARg response we decided to use a combination of pharmacological activators and inhibitors of these pathways. Cells...
ORGANISM(S): Homo sapiens 
2009-04-25 | E-GEOD-5679 | biostudies-arrayexpress
GenomicsCell-intrinsic tumorigenic functions of PPARg in bladder urothelial carcinoma [ChIP-seq]
Cell-intrinsic tumorigenic functions of PPARg in bladder urothelial carcinoma [ChIP-seq]
PRJNA702004 | ENA
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