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Analysis of binding profile of the Polycomb group proteins Calypso and Asx (PR-DUB) in Drosophila melanogaster larvae.
ORGANISM(S): Drosophila melanogaster 
PR-DUB safeguards Polycomb repression through restricting H2AK119ub1 [ChIP-seq]
PR-DUB safeguards Polycomb repression through restricting H2AK119ub1 [RNA-seq]
Molecular mechanisms of the Asx C-terminal region for genomic targeting of PR-DUB in Drosophila
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of nucleosome stacking (ATAC-Seq)
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of nucleosome stacking (RNA-Seq)
PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of nucleosome stacking (ChIP-Seq)
Polycomb Repressive Deubiquitinase (PR-DUB) removes monoubiquitin from histone H2A at lysine 119 in mammals and lysine 118 in Drosophila (H2Aub1). This reaction requires interaction of the PR-DUB catalytic subunit Bap1 with the N-terminus of its partner Asx. In Drosophila, Asx truncation mutants lac...
ORGANISM(S): Drosophila melanogaster 
2026-09-18 | GSE337505 | GEO
The Polycomb repression machinery in Drosophila comprises PRC1 that monoubiquitinates histone H2A at lysine 118 (H2Aub1) and PR-DUB, a major H2Aub1 deubiquitinase, but how H2Aub1 levels must be balanced for Polycomb repression remains enigmatic. We show that H2Aub1 is enriched at Polycomb target gen...
ORGANISM(S): Drosophila melanogaster 
2022-11-09 | GSE210235 | GEO
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