Polycomb Repressive Deubiquitinase (PR-DUB) removes monoubiquitin from histone H2A at lysine 119 in mammals and lysine 118 in Drosophila (H2Aub1). This reaction requires interaction of the PR-DUB catalytic subunit Bap1 with the N-terminus of its partner Asx. In Drosophila, Asx truncation mutants lac...
ORGANISM(S): Drosophila melanogaster