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UnknownPrognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancer.
Not available
S-EPMC3532392 | biostudies-literature
TranscriptomicsCell state transitions regulated by Slug are critical for tissue regeneration and tumor initiation [Nanostring nCounter samples]
Gene expression data of MCF10A cell subpopulations: luminal, basal and luminal. Three samples were analized. Expression of 105 selected genes was evaluated, including 5 HK genes.
ORGANISM(S): Homo sapiens 
2014-06-23 | E-GEOD-51397 | biostudies-arrayexpress
TranscriptomicsCell state transitions regulated by Slug are critical for tissue regeneration and tumor initiation [Agilent microarray samples]
Alterations that perturb differentiation and cell state transitions can lead to defects in development, function and the genesis of cancer. Studying cellular plasticity at high resolution and in real time has proven difficult using existing methods. Here, we use a quantitative approach to gain insig...
ORGANISM(S): Homo sapiens 
2014-06-23 | E-GEOD-54713 | biostudies-arrayexpress
TranscriptomicsMolecular Characterization of Basal-like and Non-Basal-like Triple-Negative Breast Cancers
Triple-negative (TN) and Basal-like (BL) breast cancer definitions have been used interchangeably to identify breast cancers that lack expression of the hormonal receptors (HR) and overexpression and/or amplification of HER2. However, both classifications when compared to each other, show substantia...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-41119 | biostudies-arrayexpress
TranscriptomicsA Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-derived Human Breast Cancer Xenografts
Translational breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. In an effort to overcome these limitations, we propagated a cohort of human breast tumo...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-34412 | biostudies-arrayexpress
TranscriptomicsPredicting Response and Survival in Chemotherapy-Treated Triple-Negative Breast Cancer
Gene expression data of pre-treatment samples of GEICAM2006-03 TNBC trial Patients were randomized to carboplatin or no carboplatin in the neoadjuvant setting In the study presented here, a well-defined cohort of 69 breast samples were used to acquire expression profiles of a total of 543 unique gen...
ORGANISM(S): Homo sapiens 
2014-08-11 | E-GEOD-58479 | biostudies-arrayexpress
TranscriptomicsXenografting of advanced stage breast cancer preserves the genomic and clonal architecture and captures luminal tumors harboring mutations and gene rearrangements in ESR1
End-stage breast cancers are clonally heterogeneous and harbor many poorly-understood treatment resistance mechanisms. We therefore established multiple Patient-Derived-Xenograft (PDX) models to study genomic events driving advanced disease. Comparative whole-genome sequencing of paired primary tu...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-46604 | biostudies-arrayexpress
TranscriptomicsSWI/SNF Chromatin-Remodeling Factor Smarcd3/Baf60c Controls Epithelial-Mesenchymal Transition by Inducing Wnt5a Signaling
We previously identified a gene signature predicted to regulate the epithelial-mesenchymal transition (EMT) in both epithelial tissue stem cells and breast cancer cells. A phenotypic RNA interference (RNAi) screen identified the genes within this 140-gene signature that promoted the conversion of me...
ORGANISM(S): Homo sapiens 
2013-08-19 | E-GEOD-40145 | biostudies-arrayexpress
TranscriptomicsPI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer
Activating mutations of PIK3CA are the most frequent genomic alterations in estrogen receptor (ER)-positive breast tumors and selective PI3Kα inhibitors are in clinical development. The activity of these agents, however, is not homogenous and only a fraction of patients bearing PIK3CA-mutant ER-posi...
ORGANISM(S): Homo sapiens 
2015-04-29 | E-GEOD-64033 | biostudies-arrayexpress
TranscriptomicsPotential Biomarkers of Long-term Benefit from Single-agent Trastuzumab or Lapatinib in HER2-positive Metastatic Breast Cancer
Gene expression data of HER2+ breast tumor samples Increasing evidence indicates that a subset of patients with HER2-positive breast cancer may achieve significant clinical benefit with anti-HER2 targeted therapy without chemotherapy. Thus, identification of biomarkers of long-term benefit from anti...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-46350 | biostudies-arrayexpress
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