Pre-clinical models

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Publication Date

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UNIPROT ID/AC

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P62136 (2)
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CHEBI ID

CHEBI:15354 (4)
CHEBI:15891 (4)
CHEBI:16857 (4)
CHEBI:17126 (4)
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CHEBI:1148 (3)
CHEBI:15366 (3)
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CHEBI:18012 (3)
CHEBI:18050 (3)
CHEBI:15422 (2)
CHEBI:16027 (2)
CHEBI:16761 (2)
CHEBI:16991 (2)
CHEBI:26523 (2)

Metabolite Name

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First Public Date

2025 (116)
2024 (90)
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2020 (45)
2021 (32)
2019 (26)
2017 (26)
2014 (26)
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2015 (9)
2016 (6)
2013 (2)

Modelling Approach

Ordinary differential equation model (6)
Computational model (4)
Other (1)

Study status

Not provided (3)
Completed (2)
Not yet recruiting (1)
Recruiting (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
IRCCS Istituto G Gaslini (2)
Roswell Park Cancer Center Buffalo, NY, USA (2)
- Platelet Research Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain - Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands - Department of Medicine, University of Oviedo, Oviedo, Spain (1)
1.Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 2.Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. (1)
1: Evotec (München) GmbH, Am Klopferspitz 19a, 82151 Martinsried, Germany 2: Cell Signaling Group, Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany (1)
Angiogenesis and Tumor Microenvironment Lab The Swiss Institute for Experimental Cancer Research (ISREC) School of Life Sciences Ecole Polytechnique Fédérale de Lausanne (EPFL) Swiss Federal Institute of Technology, Lausanne, Switzerland (1)
Bavarian Center for Biomolecular Mass Spectrometry Technische Universität München Gregor-Mendel-Straße 4 85354 Freising GERMANY (1)
Biological Mass Spectrometry Lab, Department of Translational Medicine (DiMeT), Center for Translational Research on Autoimmune & Allergic Diseases - CAAD - University of Piemonte Orientale, Corso Trieste 15/A, 28100, Novara, Italy (1)
CABIMER (1)
CABIMER-University of Sevilla (1)
Cancer Biology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University (1)
Cancer Research UK, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE (1)
Centre for Clinical Proteomics, Odense University Hospital, Sdr Boulevard 29, DK-5000 Odense C (1)
Charles Perkins Centre, University of Sydney (1)
Charles Perkins Centre, University of Sydney, Australia (1)
Chief Scientific Officer oNKo-innate Pty Ltd Laboratory Head, Huntington Laboratory Monash Biomedicine Discovery Institute Monash University Victoria Australia (1)
Core Facilities, Istituto Giannina Gaslini, Genoa, Italy (1)
Department of Biochemistry and Chemistry, LIMS, La Trobe University, Kingsbury Drive, Bundoora, Vic 3086, Australia (1)
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (1)
Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA (1)
Department of Human Molecular Genetics and Biochemistry Sackler Faculty of Medicine Tel Aviv University Israel (1)
Department of Human Structure and Repair, Laboratory of Experimental Cancer Research, Ghent University, Belgium3. Cancer Research Institute Ghent (CRIG), Ghent University, Belgium (1)
Department of Medical Biology, Health Faculty, UiT - The Arctic University of Norway, Norway. (1)
Department of Pre-Clinical Medicine, Lake Erie College of Osteopathic Medicine (1)
Dr. rer. nat. Andreas Roos Project Leader "Tissue Proteomics" Leibniz-Institut für Analytische Wissenschaften ISAS e.V. (1)
First Affiliated Hospital, School of Medicine, Zhejiang University (1)
German Cancer Research Center Heidelberg, Division: Systems Biology of Signal Transduction (1)
IRCCS G. Gaslini (1)

Keyword

APC gene (2)
Erythromycin (2)
Erythromycin Estolate (2)
Erythromycin Ethylsuccinate (2)
Erythromycin stearate (2)
Nonsense mutations (2)
Adverse events (1)
Azithromycin (1)
Azithromycin Familial Adenomatous Polyposis (FAP) APC gene nonsense mutations (1)
Familial Adenomatous Polyposis (FAP) (1)
Familial Adenomatous Polyposis (FAP). (1)
Predictive models (1)
Risk factors (1)

IsPrivate

False (13)

Submitter Keywords

FAIR-AIML (4)
Machine Learning Model (4)
Ersilia (2)
Immuno-oncology (1)
Not Peer Reviewed (1)
TransQST (1)

Classification

protozoa (1)
viruses (1)
bacteria (1)
fungi (1)

Study type

Transcription profiling by array (169)
RNA-seq of coding RNA (37)
ChIP-seq (9)
Comparative genomic hybridization by array (8)
Other (7)
Methylation profiling by array (7)
RNA-seq of non coding RNA (5)
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Observational (3)
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Methylation profiling by high throughput sequencing (2)
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Animal - High-throughput sequencing (1)
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Genotyping by array (1)
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RNA-seq of coding RNA from single cells (1)

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2005 (2)
2004 (1)
2003 (1)
2001 (1)
1982 (1)

Location

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Denmark (1)
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Greece (1)
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Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models

2026-04-29 | MTBLS14408 | MetaboLights

Development Of Pre-Clinical Murine Models For Fibrolamellar Hepatocellular Carcinoma

PRJNA1048524 | ENA

Pre-clinical models of genetically heterogeneous multiple myeloma reveal immune evasion mechanisms and predict clinical immunotherapy outcomes

PRJNA846769 | ENA

The novel atypical retinoid ST5589 down-regulates Aurora Kinase A and has anti-tumour activity in lymphoma pre-clinical models

we report characterized the preclinical activity of a new member of this class, the ST1926-derivative ST5589, in lymphomas GEP analysis of 2 lymphoma cell lines with and without treatment

ORGANISM(S): Homo sapiens

2016-01-08 | E-GEOD-66455 | biostudies-arrayexpress

Evaluating pre-clinical models for studying NASH driven HCC.

PRJNA474086 | ENA

Transcriptome profiling of colon biopsies from pre-clinical models of colitis

PRJNA859801 | ENA

Dissection of the molecular complexity of colorectal cancer in pre-clinical models identifies predictive signatures of sensitivity to EGFR inhibitors

Colorectal carcinoma (CRC) is a heterogeneous tumour entity, with only a fraction of the tumours responding to currently available therapies. A detailed understanding of the biology and genetics of CRC is a prerequisite for precision medicine. To address this challenge in clinical oncology, the Onco...

EGAS00001001752 | EGA

Effective sorafenib treatment response in a panel of genomically-characterized malignant peripheral nerve sheath tumor orthoxenograft models

Background: Malignant peripheral nerve sheath tumors (MPNST) are soft-tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 (NF1). These aggressive malignancies confer poor survival, with no effective therapy available. Methods: We generated five patient-...

ORGANISM(S): Homo sapiens

2015-04-15 | E-GEOD-60082 | biostudies-arrayexpress

Development Of Pre-Clinical Murine Models For Fibrolamellar Hepatocellular Carcinoma

Fibrolamellar hepatocellular carcinoma(FLC) is a rare form of cancer that affects primarily adolescentsand young adults. FLC tumors are typically associated with an intrachromosomal deletion resulting in expression of a fusion protein between the chaperone DNAJ1B and the protein kinase PKA. FLC isch...

ORGANISM(S): Mus musculus

2024-06-03 | GSE249325 | GEO

The importance of imperfect pre-clinical models in adolescent idiopathic scoliosis.

Not available

S-EPMC12452065 | biostudies-literature

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