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MetabolomicsSafety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
Safety and efficacy analysis of in vivo lentiviral gene therapy in pre-clinical ARC syndrome models
2026-04-29 | MTBLS14408 | MetaboLights
ProteomicsMouse apolipoproteome study - hyperlipidemic mouse models
Atherosclerotic cardiovascular disease is the leading cause of death worldwide. For decades, mouse modelling of atherosclerosis has been the mainstay for pre-clinical testing of genetic and pharmacological intervention. Mouse models of atherosclerosis depend on supraphysiological levels of circulati...
ORGANISM(S): Mus Musculus 
2022-06-20 | PXD032868 | panorama
GenomicsDevelopment Of Pre-Clinical Murine Models For Fibrolamellar Hepatocellular Carcinoma
Development Of Pre-Clinical Murine Models For Fibrolamellar Hepatocellular Carcinoma
PRJNA1048524 | ENA
ProteomicsPlatelet Proteomics to Understand the Pathophysiology of Immune Thrombocytopenia: Studies in Mouse Models
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by enhanced platelet clearance and defective platelet production. Diagnosis by exclusion and “trial-error” treatment strategies are common practice, and despite the advancement conferred by Thrombopoietin receptor agonists (TPO-RA´...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD028814 | Pride
Immune thrombocytopenia Platelets Pre-clinical mouse models Bottom-up proteomics 
GenomicsPre-clinical models of genetically heterogeneous multiple myeloma reveal immune evasion mechanisms and predict clinical immunotherapy outcomes
Pre-clinical models of genetically heterogeneous multiple myeloma reveal immune evasion mechanisms and predict clinical immunotherapy outcomes
PRJNA846769 | ENA
TranscriptomicsThe CNS-Heart Axis is a Source of Cardiac Dysfunction in Mouse Models of Huntington's Disease
Purpose: Transcriptome profiling (RNA-seq) to microarray to evaluate transcriptional changes in the heart of HD mouse models Methods: Heart mRNA profiles of 4-weeks-old wild-type (WT) and R6/2 transgenic; 15-weeks-old WT and R6/2 transgenic mice; 8-month-old WT and HdhQ150 knock-in mice; 22-month-ol...
ORGANISM(S): Mus musculus 
2014-07-15 | E-GEOD-58996 | biostudies-arrayexpress
TranscriptomicsEffective sorafenib treatment response in a panel of genomically-characterized malignant peripheral nerve sheath tumor orthoxenograft models
Background: Malignant peripheral nerve sheath tumors (MPNST) are soft-tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 (NF1). These aggressive malignancies confer poor survival, with no effective therapy available. Methods: We generated five patient-...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-60082 | biostudies-arrayexpress
TranscriptomicsComprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes.
Prion infection results in progressive neurodegeneration of the central nervous system invariably resulting in death. The pathological effects of prion diseases in the brain are morphologically well defined, such as gliosis, vacuolation, and the accumulation of disease-specific protease-resistant p...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10310 | biostudies-arrayexpress
TranscriptomicsDevelopment Of Pre-Clinical Murine Models For Fibrolamellar Hepatocellular Carcinoma
Fibrolamellar hepatocellular carcinoma(FLC) is a rare form of cancer that affects primarily adolescentsand young adults. FLC tumors are typically associated with an intrachromosomal deletion resulting in expression of a fusion protein between the chaperone DNAJ1B and the protein kinase PKA. FLC isch...
ORGANISM(S): Mus musculus 
2024-06-03 | GSE249325 | GEO
GenomicsRNA-Targeting CRISPR/Cas13d System Alleviates Disease-Related Phenotypes in Pre-clinical Models of Huntington’s Disease (Mouse).
RNA-Targeting CRISPR/Cas13d System Alleviates Disease-Related Phenotypes in Pre-clinical Models of Huntington’s Disease (Mouse).
PRJNA883965 | ENA
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