Pre-metastatic niche

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National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Dongdan Santiao 5 #, Dongcheng district, Beijing 100005, China. (1)
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Spanish National Cancer Research Centre (CNIO) Address: Melchor Fernández Almagro, 3. 28029 Madrid. SPAIN (1)
Weill Cornell Medical College (1)
Weill Cornell Medicine (1)

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Subtherapeutic-Dose of Ionizing Radiation Reprograms the Pre-Metastatic Lung Niche, Accelerating Its Formation and Promoting Metastasis

Pre-metastatic niche (PMN) formation is a critical step in metastatic progression, yet the biological effect of subtherapeutic-dose of ionizing radiation (SDIR) following radiotherapy on this process remains unclear. Using a 4T1 breast cancer mouse model, we investigated the effects of SDIR (3×0.3 G...

ORGANISM(S): Mus musculus (Mouse)

2025-07-21 | PXD062108 | Pride

Tumor exosome integrins determine organotropic metastasis

Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...

ORGANISM(S): Homo sapiens

2015-06-17 | E-GEOD-68919 | biostudies-arrayexpress

Exercise Training Modulates the Hepatic Pre-Metastatic Niche by Regulating TREM-1 Signaling

PRJNA1096058 | ENA

Molecular changes in the lung during otseosarcoma pre-metastatic niche formation

PRJNA1010191 | ENA

Engineering the pre-metastatic niche.

Not available

S-EPMC5628747 | biostudies-literature

Macrophages Promote Pre-Metastatic Niche Formation of Breast Cancer through AHR Activity

PRJNA1162872 | ENA

NFIC deficiency in endometrial cancer cells promotes pre-metastatic niche formation by destroying vascular endothelial barriers

PRJNA1329222 | ENA

Macrophages Promote Pre-Metastatic Niche Formation of Breast Cancer through AHR Activity

PRJNA1161714 | ENA

Gene expression signatures for murine alveolar type II lung epithelial cells after tumor bearing

To determine the influence of primary tumors on pre-metastatic lungs, we have employed whole genome microarray expression profiling as a discovery platform to identify gene signatures of alveolar type II epithelial cells (AT-II) in TLR3 deficient mice (Tlr3-/-) and wide-type (WT) littermates with tu...

ORGANISM(S): Mus musculus

2016-08-10 | E-GEOD-76397 | biostudies-arrayexpress

Impact of high fat diet and platelet activation on pre-metastatic niche formation

Metastasis involves dynamic interactions between tumor cells and the tumor microenvironment. Obesity has emerged as a significant contributor to tumor progression, particularly in breast cancer (BC). This study explores the impact of obesity on BC metastasis, focusing on the role of platelets and th...

ORGANISM(S): Mus musculus (Mouse)

2025-03-22 | PXD051176 | Pride

Platelets Breast cancer Pre-metastatic niche Itraq High fat diet

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