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TranscriptomicsIL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme
Several versions of SWI/SNF complexes, BAF and PBAF, have been described based on unique subunit composition. We find that T cell development in the thymus and lymphoid periphery is largely normal in the absence of the PBAF-specific component BAF180. However, BAF180-deficient Th2 cells express high...
ORGANISM(S): Mus musculus 
2012-03-26 | E-GEOD-31676 | biostudies-arrayexpress
GenomicsDynamic BRG1 Recruitment During T Helper Differentiation And Activation Reveals Distal Regulatory Elements
We found binding of the remodeling protein BRG1 was programmed by lineage and activation signals. BRG1 binding was positively correlated with gene activity at protein-coding and miRNA genes. BRG1 binding was found at promoters and distal regions, including known and novel distal regulatory element...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-23719 | biostudies-arrayexpress
TranscriptomicsCHD5, A Brain-Specific Chromatin Remodeling Enzyme, Regulates Expression Of Neuronal Genes.
CHD5 is frequently deleted in neuroblastoma, and appears to be a tumor suppressor gene; however, little is known about the role of CHD5. We found CHD5 mRNA was restricted to brain; by contrast most other remodeling ATPases were broadly expressed. CHD5 protein isolated from mouse brain was associat...
ORGANISM(S): Rattus norvegicus 
2011-09-21 | E-GEOD-27620 | biostudies-arrayexpress
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