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ProteomicsEffects of ALS-associated tRNA-derived stress-induced RNA on the transcriptomic and proteomic profile of primary neurons in vitro
LtRNA-derived stress-induced RNAs (tiRNAs) are a new class of small non-coding RNA that have emerged as important regulators of cellular stress responses. tiRNAs are derived from specific tRNA cleavage by the stress-induced ribonuclease angiogenin (ANG). Loss-of-function mutations in the ANG gene ar...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-28 | PXD046961 | Pride
Transcriptome Proteome Als Rna Neurons. 
ProteomicsActin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Abnormal intraneuronal accumulation of soluble and insoluble alpha-synuclein (alpha-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well- documented that the reversible liquid-liquid phase separation of alpha-Syn can modulate synapti...
ORGANISM(S): Homo Sapiens (human) Caenorhabditis Elegans 
2025-03-22 | PXD050719 | JPOST Repository
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