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ProteomicsEfficient Suppression of Premature Termination Codons by Engineered Pyrrolysine tRNAs
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Escherichia coli 
2025-02-20 | PXD044322 | Pride
Proteomics Mutations Premature termination codons Trna Bacteria Gfp 
ProteomicsEfficient Suppression of Premature Termination Codons by Engineered Chimeric Pyrrolysine tRNAs
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044548 | Pride
Suppressor transfer rnas (sup-trnas) Premature termination codons (ptcs) Pyrrolysine trna scaffold suppressor-trnas (pass-trnas) 
Transcriptomics3' UTR length and mRNP composition determine endocleavage efficiencies at termination codons
We aimed to study the cleavage sites of nonsense-mediated mRNA decay (NMD) substrates. Therefore, we depleted the major exoribonuclease XRN1 in human cell culture, which degrades the 3' fragments generated by SMG6-mediated endonucleolytic cleavage. Different reporter mRNAs or endogenous NMD targets ...
ORGANISM(S): Homo sapiens 
2014-11-11 | E-MTAB-2907 | biostudies-arrayexpress
UnknownEngineered transfer RNAs for suppression of premature termination codons.
Not available
S-EPMC6379413 | biostudies-literature
UnknownPremature termination codons in modern human genomes.
Not available
S-EPMC4773809 | biostudies-literature
GenomicsEfficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs
Efficient suppression of premature termination codons with alanine by engineered chimeric pyrrolysine tRNAs
PRJNA1160838 | ENA
UnknownThe unfolded protein response affects readthrough of premature termination codons.
Not available
S-EPMC4023889 | biostudies-literature
UnknownAdvances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons.
Not available
S-EPMC6016875 | biostudies-literature
UnknownInhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants.
Not available
S-EPMC7375815 | biostudies-literature
UnknownFactors influencing readthrough therapy for frequent cystic fibrosis premature termination codons.
Not available
S-EPMC5827411 | biostudies-literature
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