Pressure overload

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Organisms

Mus musculus (251)
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Repository

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Tissue

Heart (30)
Cardiac muscle cell (7)
Cell culture (5)
Left ventricle (2)
Myocardium (2)
Heart (1)
Blood (1)
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Electrically active cell (1)
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Regular ventricular cardiac myocyte (1)
T cell (1)
Ventricular cardiac muscle cell (1)

Disease

Cardiovascular system disease (11)
Heart failure (5)
Aortic valve stenosis (3)
Hypertension (1)
TAC operated 1 hour after surgery (1)
Coronary artery disease (1)
Systolic heart failure (1)

Technology Type

Mass Spectrometry (40)
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Mass spectrometry (5)
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Instrument Platform

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Liquid Chromatography MS - negative - hilic (2)
Illumina NovaSeq 6000 (1)
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Liquid Chromatography MS - alternating - reverse-phase (1)
Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - reverse phase (1)
Liquid Chromatography MS - positive - hilic (1)

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CHEBI ID

CHEBI:145573 (2)
CHEBI:184062 (1)
CHEBI:5738 (1)
CHEBI:49031 (1)
CHEBI:32528 (1)
CHEBI:7351 (1)
CHEBI:17057 (1)
CHEBI:36751 (1)
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CHEBI:69187 (1)
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CHEBI:17822 (1)
CHEBI:28757 (1)
CHEBI:37684 (1)
CHEBI:17234 (1)
CHEBI:27904 (1)
CHEBI:16802 (1)
CHEBI:27592 (1)
CHEBI:15699 (1)
CHEBI:15908 (1)
CHEBI:16857 (1)
CHEBI:17750 (1)
CHEBI:17964 (1)

Metabolite Name

Chlorogenic acid (2)
PE(16:0/18:1) (2)
Heneicosanoic acid (2)
N-Methylnicotinamide (2)
Myristelaidic acid (2)
L-Cystine (2)
L-Alanine (2)
Uracil (2)
Lumichrome (2)
Hydroxyphenyllactic acid (2)
Dethiobiotin (2)
Adenine (2)
Inosine (2)
5-(2-Azaniumylethyl)-2-hydroxyphenyl sulfate (1)
Carboxymethanesulfinyl-acetic acid (1)
N-Acetyl-S-(2-hydroxyethyl)-L-cysteine (1)
Prepacifennol epoxide (1)
4'-Chloroacetoacetanilide (1)
N-Acetyl-leu-leu-tyr (1)
Tetralithium 3-hydroxy-3-methyl-5-{[(phosphonatooxy)phosphinato]oxy}pentanoate (1)
Estra-1,3,5(10)-triene-3,16alpha-diol, dipropionate (1)
Dinitrostilbenedisulfonic acid (1)
2-Chlorooxirane (1)
7-bromo-3,3a,6,8b-tetramethyl-2,3-dihydro-1H-cyclopenta[b]benzofuran (1)
Alpha-Kosin (1)
Adenophostin a (1)
8-bromo-cGMP (1)
2,4,7,8,9-Pentachloro-3-dibenzofuranol (1)
6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one (1)
5alpha-Androstan-17beta-ol propionate (1)

IsPrivate

False (1)

First Public Date

2026 (49)
2014 (47)
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2015 (5)
2013 (4)
2016 (3)

Modelling Approach

Ordinary differential equation model (1)

Study type

Transcription profiling by array (68)
RNA-seq of coding RNA (11)
ChIP-seq (2)
Comparative genomic hybridization by array (1)
Other (1)
Single nucleus RNA sequencing (1)
RNA-seq of coding RNA from single cells (1)
RNA-seq of non coding RNA (1)

Release Date

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2005 (5)
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2002 (2)
2001 (1)

Lab affiliation

iBiMED – Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal; UnIC – Unidade de Investigação Cardiovascular, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal (3)
Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany (2)
University Medical Center Goettingen, Department of Clinical Chemistry, Core Facility Proteomics (2)
9Departments of Biochemistry and Biology and the Centre for Network Systems Biology, Boston University School of Medicine, Boston, MA, United States (1)
AG Proteomics & Bioanalytics Institut für Experimentelle Medizin Christian-Albrechts-Universität zu Kiel 24105 Kiel, Germany (1)
Associate Professor, Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Department of Pharmacology and Cancer Biology Duke University Medical Center (1)
Cardiovascular Division, King's College London, London, UK (1)
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid. (1)
Centro Nacional de Investigaciones Cardiovasculares (CNIC). CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. (1)
Core Facility Proteomics, Department of Clinical Chemistry, University Medical Center Göttingen, Germany (1)
Department of Biochemistry and Microbiology, Rutgers, the State University of New Jersey, New Brunswick, NJ, USA. (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA (1)
Department of Biochemistry, Albert Einstein College of Medicine, The Bronx, NY 10461, United States (1)
Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. (1)
Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China (1)
Department of Cardiology, Songjiang Hospital Affliated to Shanghai Jiaotong University School of Medicine (1)
Department of Cardiology, Zhongshan Hospital, Fudan University (1)
Department of Cardiovascular Physiology, European Center for Angioscience (ECAS), Medical Faculty Mannheim of Heidelberg University, Germany.German Center for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim. (1)
Department of Cell Biology and Molecular Medicine Nakamura Lab Rutgers New Jersey Medical School Rutgers Biomedical and Health Sciences Rutgers The State University of New Jersey (1)
Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Rutgers Biomedical and Health Sciences (1)
Department of Internal Medicine, Botucatu Medical School, São Paulo State University, UNESP, SP, Brazil (1)
Department of Medicine, University of California San Diego, La Jolla, California 92093 (1)
Department of Pharmacology, Harbin Medical University, Heilongjiang 163319, China (1)
Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, 30322, USA (1)
Harbin Medical University (1)
Institute of Biomedical Science, Academia Sinica (1)
Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany (1)
Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital. (1)
Key Laboratory of Medical Electrophysiology of the Ministry of Education Medical Electrophysiological Key Laboratory of Sichuan Province Institute of Cardiovascular Research, Southwest Medical University (1)
MPI Heart and Lung Research (1)

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ACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation

Branched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopathy in humans. To explore the mechanism underlying cardiac pathological hypertrophy in A...

2026-04-15 | MTBLS14207 | MetaboLights

Lipidomic profiling of heart and plasma of mice following swim training versus pressure overload

Not available

ORGANISM(S): Mus musculus

ST001019 | MetabolomicsWorkbench

Transcription profiling of mouse IL-18 knockouts vs. wild types treated with pressure overload to examine cardiac hypertrophy

Pressure overload-induced cardiac hypertrophy was examined in IL-18 knockout and littermate control mice. Experiment Overall Design: 4 groups with RNA pooled from 5-6 per group. Role of IL-18 on gene expression in cardiac hypertrophy induced by pressure overload (transaortic constriction)

ORGANISM(S): Mus musculus

2008-06-13 | E-GEOD-5129 | biostudies-arrayexpress

Transcription profiling of mouse heart samples from pressure overload and sham treated animals from wild type and Apelin knockouts reveals impaired heart function in Apelin

The endogenous peptide Apelin is crucial for maintaining heart function in pressure overload and aging Experiment Overall Design: Heart samples from Apelin knockout mice with pressure overload and sham control together with the wild-type mice with pressure overload and sham were compared

ORGANISM(S): Mus musculus

2008-06-15 | E-GEOD-7781 | biostudies-arrayexpress

Differential gene expression in adrenal medulla after cardiac pressure overload

Transcriptom analysis of microdissect adrenal medulla after 8 weeks of cardiac pressure overload caused by transverse aortic constriction. Comparative transcriptome analysis was determined using the GeneChip Mouse Genome 430 2.0 Array (Affymetrix, Santa Clara, CA, USA). Six microarrays from microdis...

ORGANISM(S): Mus musculus

2011-05-03 | E-GEOD-21829 | biostudies-arrayexpress

Differential gene expression in stellate sympathetic ganglia after cardiac pressure overload

Transcriptom analysis of stellate sympathetic ganglia after 8 weeks of cardiac pressure overload caused by transverse aortic constriction. Comparative transcriptome analysis was determined using the GeneChip Mouse Genome 430 2.0 Array (Affymetrix, Santa Clara, CA, USA). Six microarrays from stellat...

ORGANISM(S): Mus musculus

2010-02-25 | E-GEOD-18004 | biostudies-arrayexpress

Left ventricular myocardial transcriptomic profiling for target discovery in a rat model of pressure overload-induced heart failure

Left ventricular myocardial transcriptomic profiling was performed in rats subjected to transverse aortic constriction (TAC)-induced heart failure and sham-operated controls to investigate gene expression changes associated with pressure overload-induced cardiac remodeling. The dataset was used in s...

ORGANISM(S): Rattus norvegicus

2026-06-11 | E-MTAB-17114 | biostudies-arrayexpress

Transcription profiling of mouse pressure overload induced cardiomyopathy time series

Expression profiles at various time points after surgical intervention for pressure-overload induced cardiac hypertrophy and failure.

ORGANISM(S): Mus musculus

2004-06-30 | E-MEXP-105 | biostudies-arrayexpress

The cardiac phospho-proteome during pressure overload in mice

Trans-aortic constriction (TAC) is a widely used murine model to study pressure overload-induced cardiac hypertrophy and heart failure. Despite its high prevalence during aortic stenosis or chronic arterial hypertension, the global alterations in cardiac proteome and phospho-proteome dynamics follow...

ORGANISM(S): Mus musculus (Mouse)

2025-05-26 | PXD061784 | Pride

RNA-Seq of cardiac macrophages after pressure overload

RNA-Seq of cardiac macrophages 6 days after pressure overload

PRJEB41314 | ENA

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