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MetabolomicsModification of erythrocyte membrane phospholipid composition in preterm newborns with retinopathy of prematurity: The omegaROP study

N-3 polyunsaturated fatty acids (PUFAs) may prevent retinal vascular abnormalities observed in oxygen-induced retinopathy, a model of retinopathy of prematurity (ROP). In the OmegaROP prospective cohort study, we showed that preterm infants who will develop ROP accumulate the n-6 PUFA arachidonic...

2022-09-07 | MTBLS4219 | MetaboLights
MetabolomicsSurvival of the littlest: Navigating sepsis diagnosis beyond inflammation in preterm neonates
Background Sepsis diagnosis in preterm neonates is challenging due to symptom overlap with non-infectious inflammatory conditions, and slow, unreliable diagnostic practices. This study aims to identify metabolic biomarkers to elucidate sepsis pathophysiology, and enable timely, accurate diagnosis, w...
2025-07-07 | MTBLS10665 | MetaboLights
ProteomicsCharacterization of N-terminal acetylation of α-hemoglobin stabilizing protein (AHSP) by top-down high resolution mass spectrometry of oral fluids from human preterm newborns.
The project reports the identification in oral fluid samples of preterm newborns of AHSP (Alpha-hemoglobin Stabilizing Protein), an erythroid-specific protein forming stable complexes with free α-hemoglobin preventing its harmful aggregation and pro-oxidant activity during red blood cell development...
ORGANISM(S): Homo sapiens (Human) 
2025-07-18 | PXD061305 | Pride
Oral fluid top-down proteomics  preterm newborn biomarkers  alpha-hemoglobin stabilizing protein (ahsp)  lc-ms  neonatal hematological disorders 
ProteomicsEarly IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a new therapeutic target
Besides recent advances in neonatal care, preterm newborns still develop sex-biased behavioural alterations. Preterms fail to receive placental insulin-like growth factor-1 (IGF-1), a major fetal growth hormone in utero, and low IGF-1 serum levels correlate with preterm poor neurodevelopmental outco...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD047222 | Pride
Mouse model Preterm newborns Neonatal care Insulin-like growth factor-1 
ProteomicsEarly IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a new therapeutic target
Besides recent advances in neonatal care, preterm newborns still develop sex-biased behavioural alterations. Preterms fail to receive placental insulin-like growth factor-1 (IGF-1), a major fetal growth hormone in utero, and low IGF-1 serum levels correlate with preterm poor neurodevelopmental outco...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD047704 | Pride
Mouse model Neonatal care Preterm newborns Insulin-like growth factor-1 
ProteomicsMetaproteomics on preterm infant stool
Development of the gut microbiota is greatly impacted in preterm infants. Despite increasing knowledge about microbiota composition in preterm infants, knowledge about the functional signatures of the intestinal microbiota remains limited. The aim was to study transitions in microbiota activity duri...
ORGANISM(S): Bacteria (ncbitaxon:2) Homo Sapiens (ncbitaxon:9606) 
2017-10-17 | MSV000081616 | MassIVE
TranscriptomicsGlucose supply and glycolysis inhibition shape the clinical fate of preterm newborns infected with Staphylococcus epidermidis [liver]
To investigate if appropriately adjusted parenteral glucose supply may help to shift liver metabolism profiling to further prevent sepsis or improve sepsis outcomes of preterm newborns, we using a preterm pig model inoculated with Staphylococcus epidermidis to mimic the inflammation condition of pre...
ORGANISM(S): Sus scrofa 
2022-06-29 | GSE201550 | GEO
TranscriptomicsGlucose supply and glycolysis inhibition shape the clinical fate of preterm newborns infected with Staphylococcus epidermidis [cord blood]
To investigate the glycolysis inhibition effect on the inflammation responses of preterm newborns infected with Staphylococcus epidermidis, we used preterm pigs` cord blood to mimic the inflammation condition of preterm newborns at birth and stimulated with S. epidermidis and glycolysis inhibior. We...
ORGANISM(S): Sus scrofa 
2022-06-29 | GSE201539 | GEO
GenomicsGlucose supply and glycolysis inhibition shape the clinical fate of preterm newborns infected with Staphylococcus epidermidis [liver]
Glucose supply and glycolysis inhibition shape the clinical fate of preterm newborns infected with Staphylococcus epidermidis [liver]
PRJNA832221 | ENA
GenomicsGlucose supply and glycolysis inhibition shape the clinical fate of preterm newborns infected with Staphylococcus epidermidis [cord blood]
Glucose supply and glycolysis inhibition shape the clinical fate of preterm newborns infected with Staphylococcus epidermidis [cord blood]
PRJNA832151 | ENA
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