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TranscriptomicsImpaired Insulin-/IGF1-Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS-Signal
Transcriptome profiling of three models with impaired insulin/IGF1 signaling. 1. Deep sequencing of endogenous mRNA from Caenorhabditis elegans N2 var. Bristol (wildtype) and daf-2(e1370) mutant; 2. Deep sequencing of endogenous mRNA from murine embryonic fibroblasts (MEF) wildtype and irs1-/- kno...
ORGANISM(S): Caenorhabditis elegans 
2012-02-25 | E-GEOD-36041 | biostudies-arrayexpress
TranscriptomicsRNA-seq of the brain of Nothobranchius furzeri at different time points
Background: Comparison of temporal gene expression profiles (www.jenage.de) The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks 25 samples: 5 biological replicates for each age group
ORGANISM(S): Nothobranchius furzeri 
2014-07-29 | E-GEOD-52462 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing identifies O2-responsive genes in the human pathogenic fungus Aspergillus fumigatus
Low oxygen conditions are not only common to natural environments but also occur during tissue invasive growth in the human host. Only few cellular factors have been identified up to now that allow the fungus to efficiently adapt its energy metabolism to the lack of O2. In the present study, we cult...
ORGANISM(S): Aspergillus fumigatus 
2014-07-25 | E-GEOD-55943 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of arsenite
Background: Arsenite is one of the most toxic chemical substances known and is assumed to exert detrimental effects on viability even at lowest concentrations. By contrast and unlike higher concentrations, we here find that exposure to low-dose arsenite promotes growth of cultured mammalian cells. I...
ORGANISM(S): Caenorhabditis elegans 
2013-04-23 | E-GEOD-46257 | biostudies-arrayexpress
UnknownUsing Arts-Based Methodologies to Understand Adolescent and Youth Manifestations, Representations, and Potential Causes of Depression and Anxiety in Low-Income Urban Settings in Peru.
Not available
S-EPMC9737895 | biostudies-literature
TranscriptomicsDeep sequencing of endogenous mRNA from Caenorhabditis elegans in the presence and absence of rotenone at 4 different time points
Background: We here show that inhibitors of mitochondrial complex I promote physical activity, stress resistance as well as lifespan of Caenorhabditis elegans despite normal food uptake, i.e. in the absence of DR. Dietary restriction (DR) extends lifespan and promotes metabolic health in evolutionar...
ORGANISM(S): Caenorhabditis elegans 
2013-04-16 | E-GEOD-46051 | biostudies-arrayexpress
TranscriptomicsRNA-seq of C.elegans and M.musculus in the presence and absence of D-Glucosamine (GlcN)
D-Glucosamine (2-amino-2-deoxy-D-glucose, C.A.S.# 3416-24-8) (GlcN) is a freely available and commonly used dietary supplement possibly promoting cartilage health in humans which also acts as an inhibitor of glycolysis. We here find that GlcN extends C. elegans lifespan by impairing glucose metaboli...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-54853 | biostudies-arrayexpress
UnknownComparison of Administrative Database-Derived and Hospital-Derived Data for Monitoring Blood Culture Use in the Pediatric Intensive Care Unit.
Not available
S-EPMC10895403 | biostudies-literature
UnknownAssociation of Diagnostic Stewardship for Blood Cultures in Critically Ill Children With Culture Rates, Antibiotic Use, and Patient Outcomes: Results of the Bright STAR Collaborative.
Not available
S-EPMC9062771 | biostudies-literature
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