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GenomicsEpigenetic profiling in CD4 and CD8 T cells from Gravesâ?? disease patients reveals changes in genes associated with T cell receptor signaling [ChIP-seq]
In Gravesâ?? disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71952 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4 T cells and CD8 T cells were obtained from peripheral blood mononuclear cells of previously untreated patients with CLL and healthy individuals reveals chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells.
To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic leukemia (CLL) with those from age-matched healthy donors. Although the cells analyzed were not part of the...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8835 | biostudies-arrayexpress
TranscriptomicsNon-alcoholic steatohepatitis causes selective CD4+ T cell loss and promotes hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer related death. NAFLD affects a large proportion of the US population. Its incidence and prevalence are increasing to epidemic proportions around the world and is known to increase the risk of HCC. We studied how intrahepatic li...
ORGANISM(S): Mus musculus 
2016-03-10 | E-GEOD-67918 | biostudies-arrayexpress
ProteomicsThe NuRD complex is required for Thpok-mediated CD4+ T cell development
This data represent characterization of the interactome of murine Thpok. A version of Thpok (Thpok-Bio) subject to biotinylation in vivo by the BirA biotin ligase was used; to assess Thpok interactions in primary cells, Thpok-Bio was retrovirally expressed in in vitro activated CD4+ T cells from Thp...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000088126 | MassIVE
TranscriptomicsTumor-specific CD4+ T cells eradicate established melanoma
Adoptive transfer of CD4+ T cells (TRP-1 CD4+ T cells) specific for tyrp-1 (tyrosinase-related protein 1) eradicate established tumors (melanoma) in lymphopenic RAG-/- hosts. In vitro differentiated CD8+ T cells have been the primary focus of immunotherapy of cancer with little focus on CD4+ T cells...
ORGANISM(S): Mus musculus 
2010-01-14 | E-GEOD-19904 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures with lncRNAs for T-cell subsets (CD34+ and CD4+CD8+)
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-61873 | biostudies-arrayexpress
MetabolomicsFuzheng Jiedu Xiaoji Formula Enhances Anti-PD-1 Therapy for Hepatocellular Carcinoma by Inhibiting Regulatory T Cell Lipotoxicity

Background: The objective response rate of anti-programmed death receptor 1 (PD-1) immunotherapy in hepatocellular carcinoma (HCC) remains limited. The tumor immunosuppressive microenvironment mediated by regulatory T cells (Tregs) is a key bottleneck. The traditional Chinese medicine (TCM) compo...

2025-12-05 | MTBLS13458 | MetaboLights
ProteomicsHuman immune cell proteomic library
Comprehensive human immune cell proteomic spectral library which contain CD4+T cell, CD8+ T cell, NK cell, B cell, PBMC, Daudi, Jurkat, stimulated Jurkat, Molt-4, Ramos, and THP-1 were generated. This library includes 10,544 proteins groups, and 127,106 peptides.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-12 | MSV000093644 | MassIVE
TranscriptomicsPrimary and secondary CD8 T cells during acute and chronic LCMV infection
Understanding the response of memory CD8 T cells to persistent antigen re-stimulation and the role of CD4 T cell help is critical to the design of successful vaccines for chronic diseases. However, studies comparing the protective abilities and qualities of memory and naïve cells have been mostly pe...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-30962 | biostudies-arrayexpress
TranscriptomicsExpression data from human CD4 or CD8 T-cells isolated from PBMC cultured at a low cell density (LDC) or high cell density (HDC)
Research in human immunobiology is mainly based on working with peripheral blood mononuclear cells (PBMC). However, recent investigations have shown that circulating CD4+ T cells are less sensitive to several T-cell activating monoclonal antibodies (mAb) and to recall antigens as compared to tissue-...
ORGANISM(S): Homo sapiens 
2015-06-09 | E-GEOD-51288 | biostudies-arrayexpress
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