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TranscriptomicsDonor lung tissues: Control vs. Primary graft dysfunction (PGD)
Primary graft dysfunction (PGD) continues to be a major cause of early death after lung transplantation. Moreover, there remains a lack of accurate pre-transplant molecular markers for predicting PGD. To identify distinctive gene expression signatures associated with PGD, we profiled human donor lun...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-9102 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood monocyte derived macrophages treated or not with synthetic REVERB ligand GSK-4112.
Circadian biology regulates inflammatory responses in mice via the clock protein REVERBα, resulting in altered mortality and morbidity. The influence of this immune-modulation pathway in humans is unclear, but may affect outcomes after transplant. We sought to determine whether the circadian clock a...
ORGANISM(S): Homo sapiens 
2019-05-13 | E-MTAB-6478 | biostudies-arrayexpress
TranscriptomicsRNA-seq of bronchoalveolar lavage samples of lung transplant primary graft dysfunction
This is an RNA-seq study of human lung transplant recipients. Bronchoalveolar lavage cells were collected on the first day after lung transplant. We performed bulk RNA-sequencing on 19 lung transplant recipients with severe primary graft dysfunction (PGD) and 19 lung transplant recipients without ...
ORGANISM(S): Homo sapiens 
2023-02-15 | E-MTAB-12282 | biostudies-arrayexpress
TranscriptomicsHigh weight differences between donor and recipient affect early kidney graft function -a role for IL-6 signaling
The frequency of delayed function of kidney transplants varies greatly and is associated with the quality of graft, donor age, and the duration of cold ischemia time. Body weight differences between donor and recipient can affect primary graft function. The underlying mechanism is poorly understood....
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-15813 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles of PBMC Subsets in Acute GVHD Following Cord Blood Transplantation (IMS v.1)
In comparison with allogeneic hematopoietic stem cell transplantation using other sources, umbilical cord blood transplantation (UCBT) offers substantial clinical advantages including a lower incidence and severity of acute graft-versus-host disease (GVHD) despite the use of allogeneic UCB stem cell...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-10512 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles of PBMC Subsets in Acute GVHD Following Cord Blood Transplantation (IMS v.2)
In comparison with allogeneic hematopoietic stem cell transplantation using other sources, umbilical cord blood transplantation (UCBT) offers substantial clinical advantages including a lower incidence and severity of acute graft-versus-host disease (GVHD) despite the use of allogeneic UCB stem cell...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-10513 | biostudies-arrayexpress
ProteomicsProteomic analysis of primary graft dysfunction and high particle flow rate
Background: Primary graft dysfunction (PGD) remains a challenge to lung transplantation (LTx) recipients as a leading cause of poor early outcomes. New methods are needed for the rapid detection of PGD and the measurement of particle flow rate (PFR) from exhaled breath is a novel means to monitor di...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-04-05 | PXD046365 | Pride
Primary graft dysfunction Lung transplantation Non-invasive monitoring Exhaled breath particles 
GenomicsIL1β-dependent extravasation of pre-existing lung-restricted autoantibodies activates complement to promote primary graft dysfunction
IL1β-dependent extravasation of pre-existing lung-restricted autoantibodies activates complement to promote primary graft dysfunction
PRJNA870506 | ENA
TranscriptomicsGene Expression Profiles of PBMC Subsets in Acute GVHD Following Cord Blood Transplantation
This SuperSeries is composed of the following subset Series: GSE10512: Gene Expression Profiles of PBMC Subsets in Acute GVHD Following Cord Blood Transplantation (IMS v.1) GSE10513: Gene Expression Profiles of PBMC Subsets in Acute GVHD Following Cord Blood Transplantation (IMS v.2) Keywords: Super...
ORGANISM(S): Homo sapiens 
2008-12-21 | E-GEOD-10572 | biostudies-arrayexpress
GenomicsMacrophage infiltration induced by donor hypovolemia protects against severe primary graft dysfunction in mouse lung transplantation
Macrophage infiltration induced by donor hypovolemia protects against severe primary graft dysfunction in mouse lung transplantation
PRJNA657514 | ENA
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