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TranscriptomicsNeutrophil transcript abundance following 3/6 hr culture in normoxia, hypoxia and anoxia
Neutrophils are key effector cells of the innate immune response and are required to migrate and function within highly adverse micro-environmental conditions. These inflammatory sites are characterised by low levels of oxygen. We examined the relative transcript abundance detected in an apoptosis...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-968 | biostudies-arrayexpress
TranscriptomicsEpidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fueled matrix metalloproteinase production
In addition to satisfying the metabolic demands of cells, mitochondrial metabolism helps regulate immune cell function. To date, such cell-intrinsic metabolic-immunologic cross-talk has only been described operating in cells of the immune system. Here we show that epidermal cells utilize fatty acid ...
ORGANISM(S): Danio rerio 
2014-04-01 | E-GEOD-56365 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of effects of progesterone-withdrawal on uteri from decidualized mice over 4 time-points
Effect of progesterone-withdrawal in decidualized mice over 4 time-points.
ORGANISM(S): Mus musculus 
2006-12-08 | E-MEXP-932 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNAs which bind to YB-1 protein
To assess the direct association of the nucleic acid binding protein yb-1 with mature microRNAs in breast cancer. To do this we performed immunoprecipitation (IP) of YB-1 protein to pull-down linked RNAs Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-50141 | biostudies-arrayexpress
TranscriptomicsEffects of YB-1 protein reduction on microRNA abundance in breast cancer cell-lines
To assess the association of the nucleic acid binding protein yb-1 with mature microRNAs levels in breast cancer. To do this we performed YB-1 siRNA treatement in triplicates alongside an siRNA control Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used, ...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-50087 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HUVEC after stimulation with an inflammatory mediator cocktail
To understand the transcripts regulated by inflammation and how this regulation may differ between different individuals, the transcriptome of HUVECs stimulated with inflammatory mediators was examined in 9 different individuals. In the study present here, HUVEC isolates from 9 different individuals...
ORGANISM(S): Homo sapiens 
2011-07-19 | E-GEOD-23069 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HUVEC under basal (resting) conditions
To understand the biological variability that exists between different individuals, the resting (untreated) transcriptome from 15 different individuals was examined. Transcripts expressed in a bimodal manor across the 15 biological replicates were identified for further examination. In the study pre...
ORGANISM(S): Homo sapiens 
2011-07-19 | E-GEOD-23068 | biostudies-arrayexpress
TranscriptomicsDissection of cancer cell and stromal cell-derived signals in melanoma xenografts following treatment with the stromal-targeting agent DMXAA
5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a tumor vascular disrupting agent, is shown here to have substantial activity as a single agent against human A375 melanoma xenografts in nude mice (94 % hemorrhagic necrosis after 24 h, and 26 days growth delay following single dose at 25 mg/kg). CD45+ ...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-26308 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of endothelial cell apoptosis induced by serum withdrawal
To understand the regulatory relationships among EC transcripts during apoptosis using serum withdrawal time series microarray data and use this to identify master regulators of endothelial cell apoptosis. In the study presenty here, HUVEC isolates from 10 different individuals were pooled. The extr...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-23067 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model of decidulization and menstruation
A murine model that mimic the decidualization and regression observed in human was used to investigate the molecular mechanisms underlying the dynamic processes in endometrium. Ovariectomized mice were treated sequentially with steroid hormones and then, to induce decidualization, oil was injected i...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6359 | biostudies-arrayexpress
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