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Genomicsena-DATASET-MUG-14-07-2016-11:57:14:452-1424 - samples
Single-end sequencing data (trimmed to 60bp) of 104 plasma samples from donors without tumors (male=50; female=54) were merged and used to establish coverage profiles around the TSS and to establish a gene expression prediction algorithm. Dataset includes merged alignements of low coverage whole gen...
EGAD00001002254 | EGA
Genomicsena-DATASET-MUG-24-06-2016-09:50:27:418-334 - samples
RNA-Seq on an Ion Torrent Proton of corresponding tumor material of two metastasized breast cancer patients (Breast7, Breast13).
EGAD00001002216 | EGA
Genomicsena-DATASET-MUG-24-06-2016-10:36:41:861-335 - samples
Merged file of low-coverage WGS from 179 plasma DNA samples from non-cancer controls and cancer patients for assessment of size distribution of plasma nuclear DNA fragments.
EGAD00001002217 | EGA
Genomicsena-DATASET-MUG-24-06-2016-09:45:40:262-333 - samples
Low coverage whole genome sequencing plasma DNA from 50 male, 54 female non-cancer donors. For the analysis of nucleosomal positioning all data from the non-cancer controls were merged. Furthermore, two patients with metastasized breast cancer were sequenced on a NextSeq with higher depth.
EGAD00001002215 | EGA
Genomicsena-DATASET-MUG-10-03-2014-08:56:10:089-189 - samples
In order to establish copy number profiles from the various samples we prepared libraries and subjected them to whole-genome sequencing at a shallow sequencing depth (0.1x)
EGAD00001000761 | EGA
Genomicsena-DATASET-MUG-10-03-2014-08:59:23:443-190 - samples
We utilized exome sequencing for DNA obtained from saliva (germline DNA) and the four spatially separated tumor foci and 3 corresponding lymph node metastases
EGAD00001000762 | EGA
Genomicsena-DATASET-MUG-10-03-2014-09:03:11:084-191 - samples
We used targeted deep sequencing to accurately establish the allele frequencies of the mutations identified by exome sequencing
EGAD00001000763 | EGA
GenomicsInferring expressed genes by whole-genome sequencing of plasma DNA
The analysis of cell-free DNA (cfDNA) in plasma represents a rapidly advancing field in medicine. cfDNA consists predominantly of nucleosome-protected DNA shed into the bloodstream by cells undergoing apoptosis. We performed whole-genome sequencing (WGS) of plasma DNA and identified two discrete reg...
EGAS00001001754 | EGA
GenomicsDivergence between high metastatic tumor burden and low circulating tumor DNA concentration in metastasized breast cancer
Circulating tumor DNA (ctDNA) was reported to represent a highly sensitive biomarker of metastatic cancer disease directly reflecting tumor burden and dynamics. Here we investigated the role of ctDNA in patients with metastatic breast cancer. In an index patient with more than 100,000 circulating tu...
EGAS00001000625 | EGA
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