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TranscriptomicsRNA-seq of a human mammary fibroblast cell line in proliferation and IR-induced senescence with and without IL1-alpha treatment.
Transcriptomic analysis of inflammatory gene expression in a human mammary fibroblast cell line in proliferation and IR-induced senescence, with and without IL1-alpha treatment (10 pg/ml for 24 hours). Cells were induced into senescence by irradiation with 40 Gy of 120 kV X-rays and then incubated 9...
ORGANISM(S): Homo sapiens 
2026-01-01 | E-MTAB-16030 | biostudies-arrayexpress
TranscriptomicsMonocyte vs Macrophage Study
Human intestinal macrophages contribute to tissue homeostasis in noninflamed mucosa through profound down-regulation of pro-inflammatory cytokine release. Here, we show that this down-regulation extends to Toll-like receptor (TLR)-induced cytokine release, as intestinal macrophages expressed TLR3-TL...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-22373 | biostudies-arrayexpress
ModelsIL-6 Signalling
The pro-inflammatory cytokines interleukin 1 (IL-1) and 6 (IL-6) are crucially involved in the regulation of a multitude of physiological processes, in particular coordinating the immune response upon bacterial infection and tissue injury. Both interleukins induce complex signalling cascades and tri...
2314 | Cell Collective
ModelsIL-1 Signaling
The pro-inflammatory cytokines interleukin 1 (IL-1) and 6 (IL-6) are crucially involved in the regulation of a multitude of physiological processes, in particular coordinating the immune response upon bacterial infection and tissue injury. Both interleukins induce complex signalling cascades and tri...
2214 | Cell Collective
UnknownTargeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis.
Not available
S-EPMC4229982 | biostudies-literature
UnknownInterleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro.
Not available
S-EPMC5393041 | biostudies-literature
UnknownMonocyte NLRP3 inflammasome and interleukin-1β activation modulated by alpha-1 antitrypsin therapy in deficient individuals.
Not available
S-EPMC11347198 | biostudies-literature
GenomicsInterleukin-23-induced transcription factor Blimp1 promotes pathogenicity of T helper 17 cells
Interleukin-23 (IL-23) is a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecular mechanisms governing this process remain unclear. We identified the transcription factor Blimp-1 (Prdm1) as a key IL-23-induced factor that drove the inflammatory fun...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-75724 | biostudies-arrayexpress
TranscriptomicsGene expression of TCR-alpha/beta CD4- CD8- human T cells
The origin and function of human double negative (DN) TCR-alpha/beta T cells is unknown. They are thought to contribute to the pathogenesis of systemic lupus erythematosus because they expand and accumulate in inflamed organs. Here we provide evidence that human TCR-alpha/beta CD4- CD8- DN T cells...
ORGANISM(S): Homo sapiens 
2009-05-16 | E-GEOD-16130 | biostudies-arrayexpress
UnknownThe Effects of New Zealand Grown Ginseng Fractions on Cytokine Production from Human Monocytic THP-1 Cells.
Not available
S-EPMC7926829 | biostudies-literature
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