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MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
TranscriptomicsDifferential production of Type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages
Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α) and IL-1β are proinflammatory cytokines which can be essential for resistance against infection, but if produced at...
ORGANISM(S): Mus musculus 
2016-09-07 | E-GEOD-79809 | biostudies-arrayexpress
GenomicsSingle-cell RNA-sequencing of mouse islets exposed to proinflammatory cytokines
Single-cell RNA-sequencing of mouse islets exposed to proinflammatory cytokines
PRJNA656998 | ENA
GenomicsCirculating proinflammatory cytokines alter transcriptional activity within fibrotic tissue of Dupuytren’s disease patients
Circulating proinflammatory cytokines alter transcriptional activity within fibrotic tissue of Dupuytren’s disease patients
PRJNA716676 | ENA
GenomicsDeficiency of RPSA reduces binding of P65 to proinflammatory cytokines promoter regions in HSV-1 infection
Deficiency of RPSA reduces binding of P65 to proinflammatory cytokines promoter regions in HSV-1 infection
PRJNA842687 | ENA
GenomicsSingle-cell RNA-sequencing of mouse islets exposed to proinflammatory cytokines [18hrs]
Single-cell RNA-sequencing of mouse islets exposed to proinflammatory cytokines [18hrs]
PRJNA758807 | ENA
GenomicsRPSA and proinflammatory cytokines after HSV-1 infection
RPSA and proinflammatory cytokines after HSV-1 infection
PRJNA842678 | ENA
TranscriptomicsTranscription profiling of human CD14+ peripheral blood monocytes from HIV patients vs uninfected controls suggest that monocyte function is diminished during high-level HIV viremia and that this effect is mediated by chronic stimulation by type I interferons
The effect of human immunodeficiency virus (HIV) infection and high-level HIV replication on the function of monocytes was investigated. HIV-positive patients had elevated levels of spontaneous production of some or all of the monocyte proinflammatory cytokines measured (interleukin-1beta [IL-1beta]...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5220 | biostudies-arrayexpress
GenomicsRibosome protein RPSA promotes the expression of proinflammatory cytokines induced by HSV-1 infection
Ribosome protein RPSA promotes the expression of proinflammatory cytokines induced by HSV-1 infection
PRJNA842685 | ENA
GenomicsIL-17B promotes proinflammatory cytokines expression in mouse lung tissues
IL-17B promotes proinflammatory cytokines expression in mouse lung tissues
PRJNA416508 | ENA
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