Sort   by:  
 Page size 
MetabolomicsDarutigenol alleviates colitis through Akkermansia muciniphila-driven intestinal proline synthesis

Background: Gut microbiota dysbiosis is a critical contributor to the pathogenesis and progression of inflammatory bowel disease (IBD). Darutigenol (DL), a natural compound has demonstrated significant anti-inflammatory activity, but its low oral bioavailability limits its application. However, t...

2025-09-27 | MTBLS13054 | MetaboLights
MetabolomicsDarutigenol alleviates colitis through Akkermansia muciniphila-driven intestinal proline synthesis
Background: Gut microbiota dysbiosis is a critical contributor to the pathogenesis and progression of inflammatory bowel disease (IBD). Darutigenol (DL), a natural compound has demonstrated significant anti-inflammatory activity, but its low oral bioavailability limits its application. However, the ...
2026-08-21 | MTBLS15418 | MetaboLights
MetabolomicsDarutigenol alleviates ulcerative colitis via promoting Akkermansia muciniphila-mediated proline synthesis
Gut microbiota dysbiosis is associated with the occurrence and development of inflammatory bowel disease (IBD). Darutigenol (DL) is a natural compound with limited oral bioavailability, but has shown promise in the treatment of ulcerative colitis (UC). However, the precise mechanisms underlying its ...
2025-09-26 | MTBLS10395 | MetaboLights
TranscriptomicsEffect of L-Proline on mouse embryonic stem cells (ESCs)
We found that the non-essential amino acid L-Proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells (ESCs) into mesenchymal-like, spindle-shaped, highly motile, invasive pluripotent stem cells. This embryonic stem cell-to-mesenchymal-like transition (esMT) ...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-50603 | biostudies-arrayexpress
MetabolomicsEffect of Genetically Reduced Maternal Myostatin on Late Gestation Maternal, Fetal, and Placental Metabolomes in Mice.
Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength. However, maternal myostatin is not detectable in fetal cir...
2023-06-08 | MTBLS3345 | MetaboLights
GenomicsEffect of L-Proline on mouse embryonic stem cells (ESCs)
We found that the non-essential amino acid L-proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells (ESCs) into mesenchymal-like, spindle-shaped, highly motile, invasive pluripotent stem cells.This embryonic stem cell-to-mesenchymal-like transition (esMT) i...
ORGANISM(S): Mus musculus 
2013-08-31 | E-GEOD-50477 | biostudies-arrayexpress
TranscriptomicsDynamic mRNA gene expression during a nutritional upshift from proline to glutamine
Dynamic mRNA gene expression from the wildtype YSBN6 during a nutritional upshift from proline to glutamine. Glutamine was added to yeast cells growing exponentially on proline as the sole nitrogen source. A sample was taken at steady-state 10 minutes before the shift, and then 3, 7, 10, 14, 24, 56 ...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-07 | E-GEOD-54844 | biostudies-arrayexpress
MetabolomicsResearch on the quality markers of antioxidant activity of Kai-Xin-San based on spectrum-effect relationship
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
TranscriptomicsDynamic mRNA gene expression during a nutritional downshift from glutamine to proline
Dynamic mRNA gene expression from the wildtype YSBN6 during a nutritional downshift from glutamine to proline. Glutamine and proline were initially together in the media, with cells consuming exlusively glutamine (proline utilization inhibited due to nitrogen catabolite repression). The concentratio...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-07 | E-GEOD-54850 | biostudies-arrayexpress
MetabolomicsTherapeutic Effect of Buyang Huanwu Decoction on the Gut Microbiota and Hippocampal Metabolism in a Rat Model of Cerebral Ischemia

Buyang Huanwu decoction (BHD) is a well-known Chinese herbal prescription. It has been widely used in the clinical treatment of cerebral ischemia (CI) in China. However, the mechanism underlying the treatment of CI with BHD remains to be elucidated. In this study, we combined microbiomic and meta...

2022-06-02 | MTBLS4366 | MetaboLights
Sort   by:  
 Page size