Proof of concept

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- (2)
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UNIPROT ID/AC

A0A0A0MS51 (8)
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P39429 (1)
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O54910 (1)
Q60778 (1)
Q60680 (1)
P25799 (1)
Q9Z1E3 (1)

ENSEMBL ID

ENSG00000170477 (2)
ENSG00000147251 (1)
ENSG00000229353 (1)
ENSG00000247315 (1)

CHEBI ID

CHEBI:25017 (6)
CHEBI:28044 (6)
CHEBI:29016 (6)
CHEBI:26271 (5)
CHEBI:27570 (5)
CHEBI:16811 (5)
CHEBI:18257 (5)
CHEBI:24898 (5)
CHEBI:15428 (5)
CHEBI:15940 (5)
CHEBI:27266 (5)
CHEBI:17750 (5)
CHEBI:15891 (5)
CHEBI:30915 (5)
CHEBI:27897 (5)
CHEBI:17596 (5)
CHEBI:17521 (4)
CHEBI:16765 (4)
CHEBI:16675 (4)
CHEBI:28747 (4)
CHEBI:17256 (4)
CHEBI:25094 (4)
CHEBI:18237 (4)
CHEBI:15356 (4)
CHEBI:22653 (4)
CHEBI:144829 (2)
CHEBI:16412 (1)
CHEBI:48706 (1)
CHEBI:48705 (1)
CHEBI:38325 (1)

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N-acetylphenylalanine (3)
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First Public Date

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2021 (78)
2019 (64)
2014 (59)
2017 (43)
2018 (41)
2015 (19)
2013 (17)
2016 (15)
2012 (2)
2011 (1)
2010 (1)

Modelling Approach

Ordinary differential equation model (9)
Constraint-based model (3)
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Study status

Completed (10)
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Active, not recruiting (4)
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Lab affiliation

Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4 (9)
Plateforme Oncoprot, TBM-Core US 005, F-33000 Bordeaux, France (5)
Amphista Therapeutics Cambridge United Kingdom (2)
Analytics Core Facility Essen (ACE), Chemische Biologie, Universität Duisburg-Essen, ZMB, Germany (2)
Cancer Research UK Scotland Institute (Formerly the Cancer Research UK Beatson Institute) Garscube Estate Switchback Road Bearsden Glasgow, G61 1BD (2)
Department of Biochemistry and Molecular Biology and the Biomedicine Discovery Institute; Monash University; Clayton 3800; Victoria; Australia (2)
Division of Nephrology, University Hospitals Namur | Place Louise Godin 15, B-5000 Namur, Belgium (2)
OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (2)
School of Biological and Behavioural Sciences Queen Mary University of London (2)
Shandong University (2)
Universite de Montpellier LPHI UMR5235, France (2)
1 - i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; 2 - Cancer Drug Resistance Group, IPATIMUP – Institute of Molecular Pathology and Immunology, University of Porto, Rua Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal; 3 - Department of Biological Sciences, FFUP – Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal (1)
1) OMICS and Analytical Development Group, BIOSCOPE Research Group, LAQV REQUIMTE, Chemistry Department, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal (1)
1. University College London 2. Birkbeck (1)
Aalborg University (1)
Associate Professor of Biochemistry Schulich School of Medicine and Dentistry Scientist, Children’s Health Research Institute (CHRI) Medical Sciences Building 358 Western University London, Ontario N6A 5C1, Canada (1)
Associate Professor, Department of Biology, IISER Pune (1)
Associate Professor, Department of Microbiology and Immunology (1)
Basic Immune System of Plants / Protein Mass Spectrometry Max Planck Institute for Plant Breeding Research Carl-von-Linne-Weg 10, 50829 Cologne, Germany (1)
Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Biophysical Chemistry Department of Clinical Chemistry, University Medical Center Goettingen (1)
Biochemical Proteomics Group, Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, 82152-Martinsried, Germany (1)
Biological Mass Spectrometry Lab Department of Translational Medicine (DiMeT) Center for Translational Research on Autoimmune & Allergic Diseases - CAAD University of Piemonte Orientale Novara, Italy (1)
Biological mass spectrometry and proteomics group, Department of Chemistry High-resolution mass spectrometry platform, Core research facilities Guangdong provincial key laboratory for cell microenvironment and disease research Southern University of Science and Technology (SUSTech) 403, 1st research building, 1088 Xueyuan Rd., Nanshan, Shenzhen (1)
Biology department, Maynooth University, Republic of Ireland (1)
Biomolecular Mass Spectrometry and Proteomics, University Utrecht, Utrecht, The Netherlands (1)
Bioscience Institute,Faculty for Medical Sciences at Newcastle University. Newcastle-Upon-Tyne United Kingdom NE24HH (1)
CEA-Marcoule, ProGenoMIX platform, DRF-Li2D, 30207 Bagnols-sur-Ceze, France (1)
CRUK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK (1)
CSIC/UAB Proteomics Facility. IIBB-CSIC, IDIBAPS. Barcelona, Spain. (1)
Cancer Biology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University (1)

Keyword

Cetuximab (3)
Docetaxel (2)
Ostomy (colostomy, urostomy, and ileostomy) (2)
Symptom (2)
Self-management (2)
Caregiving (2)
Family research (2)
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Post-treatment care transition (2)
Pembrolizumab (2)
Capecitabine (2)
Early detection of metastases (1)
SAR444245 (1)
TGF- beta activated (1)
Trimebutine (1)
Sedation-free (1)
Colonic (1)
Kappa (1)
Opioid agonist (1)
Pain management (1)
Oral (1)
Hydrogen sulfide (1)
Peripheral (1)
Elemental Diet (1)
Omomyc (1)
MYC-Inhibitor (1)
Feasibility (1)
Peritoneal (1)
Inoperable (1)

IsPrivate

False (15)

Model Flag

Non Kinetic (2)

Submitter Keywords

Immuno-oncology (2)

Classification

bacteria (11)
viruses (2)
protozoa (2)
fungi (1)

Modification

4'-dihydroxyphenylalanine (1)

Study type

Transcription profiling by array (118)
Interventional (28)
RNA-seq of coding RNA (16)
Other (10)
Comparative genomic hybridization by array (6)
ChIP-seq (5)
Observational (5)
RNA-seq of coding RNA from single cells (4)
RNA-seq of non coding RNA (4)
Unknown experiment type (2)
Bisulfite-seq (2)
DNA-seq (2)
Methylation profiling by array (2)
Cell line - One-color microarray (1)
High-throughput sequencing (1)
Genotyping by array (1)
Antigen profiling (1)
Transcription profiling by RT-PCR (1)
ATAC-seq (1)
Hi-C (1)
Proteomic profiling by array (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

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2023 (1835)
2025 (1793)
2021 (1644)
2024 (1609)
2020 (1327)
2019 (1049)
2018 (908)
2017 (702)
2016 (601)
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2011 (140)
2010 (120)
2009 (60)
2008 (57)
2007 (25)
2005 (11)
2006 (11)
2004 (6)
2003 (3)
2002 (2)

Location

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France (6)
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Italy (4)
Canada (4)
Germany (3)
Spain (3)
Australia (3)
Switzerland (3)
Russia (2)
Belgium (2)
United Kingdom (2)
Japan (2)
Hong Kong (1)
Singapore (1)
Romania (1)
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Chile (1)
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Poland (1)
Hungary (1)
Austria (1)

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3D'omics: Proof-of-concept fibre swine trial

BioProject PRJEB100724 at https://www.ebi.ac.uk/ena/browser/view/PRJEB100724

2025-11-12 | MTBLS13210 | MetaboLights

Assessing the Feasibility of In Vitro Assays in Combination with Biological Matrices to Screen for Endogenous CYP450 Phenotype Biomarkers Using an Untargeted Metabolomics Approach—A Proof of Concept Study

Cytochrome P450 (CYP) enzymes are crucial for drug metabolism, yet inter-individual variability in their activity remains a significant clinical challenge. Current phenotyping methods are often impractical or even impossible, particularly in forensic toxicology and vulnerable populations. This pr...

2025-12-12 | MTBLS13325 | MetaboLights

Online Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted volatile metabolomics for studying emerging complex biopesticides: A proof of concept

This work introduces a novel online Headspace-Solid Phase Microextraction-Gas Chromatography-Mass Spectrometry-based untargeted metabolomics approach, suggested as an alternative tool to study the environmental fate of volatile xenometabolites in emerging complex biopesticides, e.g. the Myrica gale ...

2021-01-26 | MTBLS2026 | MetaboLights

Untargeted food chemical safety assessment: A proof-of-concept on two analytical platforms and contamination scenarios of tea (Black tea study)

This study aims at assessing the capability of comparing and combining different instrumental platforms in an untargeted approach with a view of detecting chemical contaminants in food matrices at low levels. A strategy based on liquid chromatography-high resolution mass spectrometry (LC-HRMS) and c...

2019-02-12 | MTBLS772 | MetaboLights

Untargeted food chemical safety assessment: A proof-of-concept on two analytical platforms and contamination scenarios of tea (Green tea study)

2019-02-12 | MTBLS771 | MetaboLights

3D'omics: proof-of-concept mannan fibre swine trial

PRJEB100724 | ENA

The impact of nutritional supplementation on sweat metabolomic content

Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...

2021-03-15 | MTBLS2427 | MetaboLights

AsthmaNet Proof of Concept Study of Alendronate for Asthma (ALFA_BioLINCC)

PRJNA1431496 | ENA

AsthmaNet Proof of Concept Study of Alendronate for Asthma (ALFA_BioLINCC)

PRJNA1431497 | ENA

Exploring kidney allograft rejection: A proof-of-concept study using spatial transcriptomics

PRJNA1030317 | ENA