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GenomicsProstaglandin D2 synthase controls Schwann cells metabolism
Prostaglandin D2 synthase controls Schwann cells metabolism
PRJNA925476 | ENA
TranscriptomicsThe vitamin D receptor and inducible nitric oxide synthase associated pathways in the development of acquired resistance to Cooperia oncophora infection in cattle
Cooperia oncophora is an economically important gastrointestinal nematode in ruminants. Acquired resistance to Cooperia oncophora infection in cattle develops rapidly as a result of prior infections. Naïve cattle, when given a primary infection of high-dose infective L3 larvae, develop a strong immu...
ORGANISM(S): Bos taurus 
2011-09-28 | E-GEOD-24402 | biostudies-arrayexpress
ProteomicsA cleavable chelation-assisted biotin probe enables the discovery of a celecoxib binding site on prostaglandin E synthase
The coxibs are a subset of non-steroidal anti-inflammatory drugs (NSAIDs) that selectively target cyclooxygenase-2 (COX-2) to inhibit prostaglandin signaling and reduce inflammation. However, only celecoxib remains in use, necessitating exploration of broader mechanisms of the coxibs. Here, we rep...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD014299 | Pride
Human 
TranscriptomicsFeedback amplication of fibrosis through matrix stiffening and COX-2 suppression
We tested the hypothesis that increasing matrix stiffness on which normal human lung fibroblasts are grown promotes the expression of a fibrogenic cellular transcriptomic program. Keywords: Human lung fibroblast, matrix stiffness, PTGS2, COX-2, Prostaglandin E2 Total RNA extracted from normal human...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-22011 | biostudies-arrayexpress
GenomicsGlomerular Haematopoietic Prostaglandin D Synthase‐Prostaglandin D2 Axis Contributes to the Periodontitis‐Related Exacerbation of Diabetic Nephropathy in KK‐Ay Mice
Glomerular Haematopoietic Prostaglandin D Synthase‐Prostaglandin D2 Axis Contributes to the Periodontitis‐Related Exacerbation of Diabetic Nephropathy in KK‐Ay Mice
PRJNA1086826 | ENA
TranscriptomicsProstaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia
Testosterone is necessary for the development of male pattern baldness, known as androgenetic alopecia (AGA); yet the mechanisms for decreased hair growth in this disorder are unclear. Here, we show that prostaglandin D2 synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compa...
ORGANISM(S): Homo sapiens 
2012-03-26 | E-GEOD-36169 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse gastric tumor models
Transgenic mice with prostaglandin E2 pathway in stomach develops gastric tumors. Simultaneous activation of both Wnt pathway and prostaglandin E2 pathway causes gastric adenocarcinoma. Combination of prostaglandin E2 pathway activation and suppression of BMP pathway leads to the development of gast...
ORGANISM(S): Mus musculus 
2009-07-02 | E-GEOD-16902 | biostudies-arrayexpress
TranscriptomicsMutual Antagonistic Relationship Between Prostaglandin E2 and Interferon-(gamma): Implications for Rheumatoid Arthritis
PGE2 is a major mediator of inflammation and is present at high concentrations in the synovial fluid of rheumatoid arthritis (RA) patients. PGE2, acting through the EP4 receptor, has both pro- and anti-inflammatory roles in vivo. To shed light on this dual role of PGE2, we investigated its effects ...
ORGANISM(S): Homo sapiens 
2008-05-29 | E-GEOD-11575 | biostudies-arrayexpress
UnknownMicrosomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis.
Not available
S-EPMC3182462 | biostudies-literature
TranscriptomicsProstaglandin D2 synthase controls Schwann cells metabolism
We previously reported that in the absence of Prostaglandin D2 synthase (L–PGDS) peripheral nerves are hypomyelinated in development and that with aging they present aberrant myelin sheaths. We now demonstrate that L–PGDS is part of a coordinated program aiming at preserving myelin integrity. In viv...
ORGANISM(S): Mus musculus Rattus norvegicus 
2026-02-11 | GSE223246 | GEO
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