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MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsMAGL Targeted PROTAC Degrader Simultaneously Enhances P53 for Synergistic Treatment of Glioblastoma Stem Cell
This study focuses on the protein degradation effects of the MAGL inhibitor JZL184 and the newly synthesized MAGL-PROTAC on MAGL.
ORGANISM(S): Homo Sapiens 
2024-12-02 | PXD058506 |
ProteomicsPosternak_PROTACdegradation_P124_Lumos
The files are associated with a manuscript submitted for publication by Ganna Posternak et al. The main goal of this paper was functionally characterize the mechanism of action of a PROTAC designed to target BRAFV600E. This dataset provides a proteome-wide view of protein degradation after treatment...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-10 | MSV000085271 | MassIVE
ProteomicsPosternak_PROTACagainstBRAFV600E_P124_Lumos
The files are associated with a manuscript submitted for publication by Ganna Posternak et al. The main goal of this paper was functionally characterize the mechanism of action of a PROTAC designed to target BRAFV600E.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-07 | MSV000084551 | MassIVE
UnknownOrthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET.
Not available
S-EPMC11696238 | biostudies-literature
ProteomicsMultiplexed proteome dynamics profiling of JQ1-PROTAC
Goal of this experiment was the differentiation of direct targets of induced degradation of the JQ1-PROTAC from downstream regulatory effects.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008637 | Pride
Vhl Protac Mpdp Jq1 
UnknownThe efficacy of ball blankets on insomnia in depression in outpatient clinics: study protocol for a randomized crossover multicentre trial.
Not available
S-EPMC7430021 | biostudies-literature
ProteomicsThe effect of an MLK3-targeting PROTAC on protein levels in model breast cancer cell lines.
The objective of the study was to explore how a new compound (CEP1347-VHL-02 PROTAC) which facilitates the breakdown of mitogen-activated protein kinase kinase kinase 11 (MLK3), affects the protein quantities in the total cell extracts from specific breast cancer cell models. The cell lines used in ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD050260 | Pride
Mlk3 Cep1347-vhl-02 protac Hcc1806 Mcf-7 Mda-mb-468 
GenomicsDevelopment of MDM2-targeting PROTAC technology for advancing bone regeneration
Development of MDM2-targeting PROTAC technology for advancing bone regeneration
PRJNA1074395 | ENA
GenomicsFunctional characterization of a PROTAC directed against BRAFV600E
Functional characterization of a PROTAC directed against BRAFV600E
PRJNA624659 | ENA
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