Protease protection assay

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Transcriptomics (96)
Proteomics (87)
Unknown (48)
Genomics (17)
Metabolomics (7)

Organisms

Aerococcus urinae NBRC 15544 = CCUG 36881 (81)
Andropogon gerardi (81)
Bacteria (81)
Canis lupus familiaris (81)
Cnidaria (81)
Ectopseudomonas oleovorans CECT 5344 (81)
Ensifer adhaerens (81)
Enterococcus faecalis (81)
Globicatella sanguinis (81)
Halictus scabiosae (81)
Human immunodeficiency virus 1 (81)
Mesocricetus auratus (81)
Methylohalobius crimeensis 10Ki (81)
Miscanthus x giganteus (81)
Mus musculus (44)
Homo sapiens (42)
Saccharomyces cerevisiae (5)
Bos taurus (3)
Gallus gallus (3)
Porphyromonas gingivalis (2)
Schizosaccharomyces pombe (2)
Salmo salar (2)
Heterocephalus glaber (2)
Sus scrofa (2)
Drosophila melanogaster (2)
Trichinella spiralis (1)
Gossypium tomentosum (1)
Rattus norvegicus (1)
Danio rerio (1)
Paraprevotella clara (1)

Repository

biostudies-arrayexpress (110)
pride (81)
MetaboLights (7)
MassIVE (4)
EGA (3)
jPOST (2)

Tissue

Colon (23)
Colon epithelial cell (23)
Cell culture (18)
SW-480 cell (12)
HCT-116 cell (11)
Epithelial cell (4)
Liver (4)
Lung (4)
Brain (3)
Kidney (3)
Leaf (3)
Plant cell (3)
Fibroblast (2)
Fibroblast of lung (2)
Heart (2)
Macrophage (2)
Mesothelial fibroblast (2)
Pleural mesothelium (2)
Whole body (2)
Accessory sex gland (1)
B cell (1)
Bacterial protein (1)
Blood cell (1)
Blood platelet (1)
Brown adipose tissue (1)
Culture condition:yeast extract-grown cell (1)
Defense response to fungus (1)
Dendritic cell (1)
Embryonic stem cell (1)
Extracellular membrane-bounded organelle (1)

Disease

Colon cancer (23)
Normal (6)
Cryptococcosis (3)
Lung cancer (2)
Malignant pleural mesothelioma (2)
Multiple sclerosis (1)
Xenografts with H1299 cell line (1)
Non-small cell lung carcinoma (1)
Acute leukemia (1)
Brain cancer (1)
Brain glioblastoma multiforme (1)
Diabetic retinopathy (1)
Duchenne muscular dystrophy (1)
Gastric adenocarcinoma (1)
Gonorrhea (1)
Melanoma (1)
Perrault syndrome (1)
Severe acute respiratory syndrome (1)
Type 1 diabetes mellitus (1)
Wounds and Injuries (1)

Technology Type

Mass Spectrometry (81)
Shotgun proteomics (56)
Bottom-up proteomics (12)
Data-independent acquisition (5)
Mass spectrometry assay (4)
Data-dependent acquisition (4)
Mass spectrometry (3)
Affinity purification coupled with mass spectrometry proteomics (3)
Gel-based experiment (3)
Top-down proteomics (2)
Mass spectrometry imaging (1)
Metaproteomics (1)
SWATH MS (1)

Instrument Platform

NextSeq 500 (8)
Illumina NovaSeq 6000 (6)
NextSeq 2000 (3)
Illumina HiSeq 2500 (3)
Liquid Chromatography MS - positive - reverse phase (2)
ScanArray Express HT [PerkinElmer] (1)
NextSeq 550 (1)
Illumina HiSeq 4000 (1)
LTQ Orbitrap Elite (1)
Q Exactive (1)
Q Exactive Plus (1)
QTRAP 6500 (1)
PTR-MS (1)
Tandem Gas Chromatography MS - positive (1)
Liquid Chromatography MS - alternating - reverse phase (1)
Liquid Chromatography MS - (1)
Gas Chromatography MS - positive (1)
Liquid Chromatography MS - negative - reverse-phase (1)
Liquid Chromatography MS - positive - reverse-phase (1)
Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - positive - hilic (1)

Publication Date

2022 (33)
2025 (18)
2026 (15)
2013 (13)
2010 (13)
2023 (12)
2021 (11)
2012 (11)
2015 (10)
2011 (10)
2008 (9)
2014 (8)
2024 (6)
2007 (6)
2017 (6)
2019 (5)
2009 (5)
2020 (5)
2016 (4)
2006 (3)
2002 (1)

CHEBI ID

CHEBI:15688 (2)
CHEBI:30830 (2)
CHEBI:75555 (2)
CHEBI:16113 (2)
CHEBI:58262 (1)
CHEBI:34452 (1)
CHEBI:15342 (1)
CHEBI:190016 (1)
CHEBI:173491 (1)
CHEBI:134539 (1)
CHEBI:93822 (1)
CHEBI:50235 (1)
CHEBI:156118 (1)
CHEBI:183804 (1)
CHEBI:183249 (1)
CHEBI:183826 (1)
CHEBI:10217 (1)
CHEBI:35189 (1)
CHEBI:89632 (1)
CHEBI:167093 (1)
CHEBI:167090 (1)
CHEBI:167089 (1)
CHEBI:167088 (1)
CHEBI:167087 (1)
CHEBI:23046 (1)
CHEBI:167086 (1)
CHEBI:167085 (1)
CHEBI:167083 (1)
CHEBI:89053 (1)
CHEBI:88452 (1)

Metabolite Name

(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (1)
4-Diphosphocytidyl-2-C-methylerythritol (1)
2-C-Methyl-d-erythritol-2,4-cyclopyrophosphate (1)
Trehalose-6-phosphate (1)
Thymidine 5'-monophosphate degr prod (1)
Thioctamide (1)
Tetracosanoic acid, methyl ester (1)
Pyridine-2,3-dicarboxylic acid (1)
Phosphomycin (1)
P-benzoquinone (1)
O-phosphonothreonine (1)
N-Acetyl-N-formyl-5-methoxykynurenamine (1)
Methyl octadecanoate (1)
Methyl decanoate (1)
Lyxonic acid, 1,4-lactone (1)
Estradiol (1)
Dithioerythritol (1)
Cytidine-monophosphate (1)
Cytidine-5'-monophosphate (1)
Citraconic acid degr1 (1)
Cetadiol (1)
Beta-Glutamic acid (1)
Acenaphthenequinone (1)
6-hydroxy caproic acid dimer (1)
5-Methylresorcinol (1)
3-aminopropionitrile (1)
3'-adenylic acid (1)
2-Ketovaleric acid (1)
2-hydroxy-3-isopropylbutanedioic acid (1)
2'-Deoxycytidine 5'-triphosphate degr prod (1)

Modification

-17.026549 (1)
-18.010565 (1)
15.994915 (1)
4-tetrahydrothiazine-3-carboxylic acid (1)
42.010565 (1)
57.021464 (1)

Study type

Transcription profiling by array (52)
RNA-seq of coding RNA (15)
ChIP-seq (12)
ATAC-seq (4)
Other (4)
Methylation profiling by array (4)
ChIP-chip by tiling array (3)
Bisulfite-seq (3)
RNA-seq of coding RNA from single cells (3)
Comparative genomic hybridization by array (2)
Transcription profiling by SAGE (1)
Unknown experiment type (1)
Cell line - High-throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
MicroRNA profiling by array (1)
DNA-seq (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of total RNA (1)

Release Date

2010 (15)
2015 (14)
2012 (14)
2013 (13)
2011 (10)
2023 (9)
2008 (9)
2014 (8)
2009 (8)
2022 (8)
2021 (7)
2026 (6)
2024 (6)
2007 (6)
2025 (5)
2016 (4)
2006 (3)
2018 (3)
2019 (2)
2020 (2)
2002 (1)
2017 (1)
2005 (1)
2001 (1)
1998 (1)
1997 (1)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (24)
Molecular and Cellular Biology, University of Guelph, Canada (2)
1. Department of Chemical Sciences, University of Naples Federico II, Naples 80126, Italy 2. CEINGE Advanced Biotechnologies, University of Naples Federico II, Naples 80145, Italy (1)
1.Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, USA. 2. Department of Pediatrics, Harvard Medical School, Boston, MA, USA. (1)
Aarhus University Department of Biomedicine Høegh-Guldbergsgade 10 DK-8000 Aarhus C (1)
Beijing, You An Men Wai Xi Tou Tiao No.10, Capital Medical University, Beijing Laboratory of Oral Health (1)
Cancer Science Institute of Singapore, National University of Singapore, Singapore (1)
Clinic and Polyclinic for Pediatric and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany (1)
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China (1)
Department of Biological Sciences, Department of Chemistry, Vanderbilt University. Department of Pathology, Microbiology and Immunology, Vandberbilt University Medical Center (1)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. Department of Cell Biology, Harvard Medical School, Boston, MA, USA. (1)
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX (1)
Department of Ecology and Genetics, Uppsala University (1)
Department of Life Science, Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan. (1)
Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College (1)
Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Rd. E., Guelph, Ontario, Canada, N1G 2W1 (1)
Department of Plant Protection, Shenyang Agricultural University (1)
Dept Biomedical Sciences, School of Medicine and Health Sciences, Institute of Neurosciences, Universitat de Barcelona, E-08036 Barcelona (1)
Deputy Head (Research), Department of Biochemistry and Molecular Biology Head Immunoproteomics Laboratory Infection and Immunity Program Room 214, level 2, 15 Innovation Walk Monash Biomedicine Discovery Institute Monash University, Clayton Campus Clayton 3800 Victoria Australia (1)
Division of Chemistry I, Department of Medical Biochemistry & Biophysics, Karolinska Institutet (1)
Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis Department of Cell Biology & Physiology, Washington University, St. Louis (1)
Finley and Gygi lab Cell Biology Department Harvard Medical School US (1)
Fujian Provincial Key Laboratory of Plant Functional Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, China (1)
Functional Proteomics, ICR (1)
Guangdong Cardiovascular Institute, Medical Research Institute, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University (1)
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences in Olsztyn, Poland (1)
Institute of Bioengineering, EPFL (1)
Institute of Bioingineering, EPFL (1)
Institute of Biomedicine, Department of Microbiology, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden (1)
Institute of Molecular Biology, Mainz (1)

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TAILS identifies candidate substrates and biomarkers of ADAMTS7, a therapeutic protease target in coronary artery disease

MacDonald BT, Keshishian H, Mundorff CC, Arduini A, Lai D, Bendinelli K, Popp NR, Bhandary B, Clauser KR, Specht H, Elowe NH, Laprise D, Xing Y, Kaushik VK, Carr SA, Ellinor PT. Loss-of-function mutations in the secreted enzyme ADAMTS7 (a disintegrin and metalloproteinase with thrombospondin motifs ...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2021-12-03 | MSV000088508 | MassIVE

Identification of bistable populations of Porphyromonas gingivalis that differ in epithelial cell invasion.

Bistable populations of bacteria give rise to two or more subtypes that exhibit different phenotypes. We have explored whether the periodontal pathogen, Porphyromonas gingivalis, exhibits bistable invasive phenotypes. Using a modified cell invasion assay, we show for the first time that there are tw...

ORGANISM(S): Porphyromonas gingivalis

2010-08-31 | E-GEOD-23021 | biostudies-arrayexpress

A protease protection assay for the detection of internalized alpha-synuclein pre-formed fibrils.

Not available

S-EPMC7837481 | biostudies-literature

Development and utility of an in vitro, fluorescence-based assay for the discovery of novel compounds against dengue 2 viral protease.

Not available

S-EPMC4979183 | biostudies-literature

Multi-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights

p53 prevents neurodegeneration by regulating synaptic genes

DNA damage has been implicated in neurodegenerative disorders, including Alzheimer’s disease and other tauopathies, but the consequences of genotoxic stress to postmitotic neurons are poorly understood. Here we demonstrate that p53, a key mediator of the DNA damage response, plays a neuroprotective ...

ORGANISM(S): Drosophila melanogaster

2015-01-06 | E-GEOD-40418 | biostudies-arrayexpress

Transcriptome uterus

cDNA microarrays were used to identify the expression of the genes in uterus by comparison with two others regions of the oviduct not involved in the shell deposition. A total of 605 sequences specifically over-expressed were revealed. The expression of 15 of them was also confirmed using qRT-PCR, a...

ORGANISM(S): Gallus gallus

2010-05-06 | E-GEOD-17267 | biostudies-arrayexpress

Challenge of vaccinated and unvaccinated salmon with Aeromonas salmonicida

The study searched for the correlates of vaccine protection against furunculosis. After pathogen challenge of vaccinated (V) and unvaccinated (N) fish, hepatic gene expression was compared in salmon with high resistance (HR, individual samples) and low resistance (LR, pooled samples) Two-condition e...

ORGANISM(S): Salmo salar

2010-05-05 | E-GEOD-18120 | biostudies-arrayexpress

LC-MS/MS data of Tinospora cordifolia

Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimers disease through untargeted metabolomics and netwo...

ORGANISM(S): Tinospora Cordifolia (ncbitaxon:285590)

2024-11-04 | MSV000096283 | MassIVE

Identification of novel substrates of the human mitochondrial ClpXP protease: Implications to Perrault syndrome type 3

The ClpXP ATP-dependent unfoldase-protease complex plays important roles in maintaining protein homeostasis in the mitochondria. Pathogenic variants of CLPP have been identified in patients with Perrault syndrome type 3 (PRLTS3), a rare recessive mitochondrial disease characterized by sensorineural ...

ORGANISM(S): Homo sapiens (Human)

2026-08-13 | PXD070104 | Pride

Human Timstof ht

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