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MetabolomicsA multi-omics dataset of heat-shock response in the yeast RNA binding protein Mip6 (NMR assay)

Gene expression is a biological process regulated at different molecular levels, including chromatin accessibility, transcription, and RNA maturation and transport. In addition, these regulatory mechanisms have strong links with cellular metabolism. Here we present a multi-omics dataset that capt...

2020-02-14 | MTBLS1320 | MetaboLights
MetabolomicsIntegrative of Single-Cell RNA Sequencing and Metabolomics Decipher the Imbalanced Lipid-Metabolism in Maladaptive Immune Responses during Sepsis
To identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis. Machine learning algorithms were applied for screening hubgenes related to lipid metabolism. CIBERSORT and Single-sample GSEA were employed for assessing the immune cell infil...
2024-09-26 | MTBLS7315 | MetaboLights
MetabolomicsHuman gut microbiota and plasma metabolomics in Mn-glucose metabolism correlation

Previous epidemiological and laboratorial studies have demonstrated a close relationship between plasma manganese (Mn) levels and type 2 diabetes (T2D), however, the underlying mechanism remains undisclosed. In this study, we employed a comprehensive approach that integrated fecal 16S rRNA sequen...

2025-12-14 | MTBLS13155 | MetaboLights
GenomicsChromatin accessibility associates with protein-RNA correlation in human cancer
Chromatin accessibility associates with protein-RNA correlation in human cancer
PRJNA682135 | ENA
Proteomics,Multiomicsp53-regulated networks of protein, mRNA, miRNA and lncRNA expression revealed by integrated pSILAC and NGS analyses
We determined the effect of p53 activation on de novo protein synthesis using quantitative proteomics of newly synthesized proteins (pulsed stable isotope labeling with amino acids in cell culture, pSILAC) in combination with mRNA and non-coding RNA expression analyses by next generation sequencing ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-05-24 | MSV000079767 | MassIVE
TranscriptomicsCorrelation between expression levels of different tumors measured by poly(A)+RNA and aRNA
Zhao et al. Amplification Table 7 This experiment was designed to determine the correlation between expression levels of defferent tumors (BC2 and BC91) measured by poly(A)+RNA and aRNA for each tumor. Total RNA was amplified using the Jeffrey lab protocol with G50 cleanup. Set of arrays organized b...
ORGANISM(S): Homo sapiens 
2005-11-03 | E-GEOD-3563 | biostudies-arrayexpress
TranscriptomicsGlobal Target mRNA Specification and Regulation by RNA-Binding Protein ZFP36/Tristetraprolin/TTP [PAR-CLIP]
Tristetraprolin/ZFP36/TTP and ELAVL1/HuR are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich sequences but have antagonistic roles. While ELAVL1 binding has been profiled in several studies, the precise in vivo binding specificity of ZFP36 has not been investigated o...
ORGANISM(S): Homo sapiens 
2013-12-24 | E-GEOD-53184 | biostudies-arrayexpress
TranscriptomicsConservation of mRNA and protein expression during development of C. elegans
Spatiotemporal control of gene expression is crucial for development and subject to evolutionary changes. Although proteins are the final product of most genes, the developmental proteome of an animal has not yet been comprehensively defined, and the correlation between RNA and protein abundance dur...
ORGANISM(S): Caenorhabditis elegans 
2014-01-23 | E-GEOD-53359 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation
This SuperSeries is composed of the following subset Series: GSE26376: Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (miRNA) GSE26377: Microarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (gene expression) Refer to indi...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26379 | biostudies-arrayexpress
TranscriptomicsIntegrative regulatory mapping indicates that the RNA-binding protein HuR (ELAVL1) couples pre-mRNA processing and mRNA stability [sequence data]
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly understood. We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-...
ORGANISM(S): Homo sapiens 
2011-08-19 | E-GEOD-29779 | biostudies-arrayexpress
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