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GenomicsThe Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis
Histone variants play crucial roles in gene expression, genome integrity and chromosome segregation. However, to what extent histone variants control chromatin architecture remains largely unknown. Here, we show that the previously uncharacterized histone variant H2A.W plays a crucial role in conde...
ORGANISM(S): Arabidopsis thaliana 
2014-07-05 | E-GEOD-50942 | biostudies-arrayexpress
TranscriptomicsCondensin plays a role in both interphase nuclei and premature chromosome condensation
Purpose: to identify how condensin I removal affects gene expression globally. Methods: Chicken DT40 CAP-H KO cells were treated with or without dox for 36 h. Total RNA samples were extracted and subjected to sequencing using an Illumina Hiseq2000 platform. Library preparation and Illumina sequencin...
ORGANISM(S): Gallus gallus 
2017-05-03 | E-GEOD-74892 | biostudies-arrayexpress
ProteomicsUnderstanding condensation domain selectivity in non-ribosomal peptide biosynthesis: structural characterization of the acceptor bound state
Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a peptide bond between two peptidyl carrier protein (PCP)...
ORGANISM(S): Escherichia coli 
2021-04-07 | PXD024015 | Pride
Non-ribosomal peptide  biosynthesis  condensation domain  peptidyl carrier protein  biocatalysis 
ProteomicsUnderstanding condensation domain selectivity in non-ribosomal peptide biosynthesis: structural characterization of the acceptor bound state
Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a peptide bond between two peptidyl carrier protein (PCP)...
ORGANISM(S): Escherichia coli 
2021-05-28 | PXD024004 | Pride
Non-ribosomal peptide  biosynthesis  condensation domain  peptidyl carrier protein  biocatalysis 
TranscriptomicsBudding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [PK-ChIP]
Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-22 | E-GEOD-42457 | biostudies-arrayexpress
ProteomicsAn adaptive biomolecular condensation response is conserved across environmentally divergent species
Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and biomolecular condensation of protein and mRNA into structures k...
ORGANISM(S): Candida albicans (Yeast) 
2024-03-03 | PXD044702 | Pride
Bimolecular condensation Yeast Dia lc-ms/ms 
ProteomicsAn adaptive biomolecular condensation response is conserved across environmentally divergent species
Cells must sense and respond to sudden maladaptive environmental changes—stresses—to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved responses: growth arrest, a specific transcriptional response, and biomolecular condensation of protein and mRNA into structures k...
ORGANISM(S): Saccharomyces kudriavzevii ZP591 Kluyveromyces marxianus DMKU3-1042 Saccharomyces cerevisiae (Baker's yeast) 
2024-03-03 | PXD044970 | Pride
Hydrogen-deuterium exchange Yeast Condensation 
GenomicsIdentification of a novel Bromodomain / Casein Kinase II / TAF-containing complex as a regulator of mitotic condensin function
ABSTRACT: Condensin is a central regulator of mitotic genome structure, with mutants showing poorly condensed chromosomes and profound segregation defects. Here we identify the fission yeast NCT complex, comprising the Nrc1 BET-family tandem bromodomain protein (SPAC631.02), Casein Kinase II (CKII) ...
ORGANISM(S): Schizosaccharomyces pombe 
2014-01-10 | E-GEOD-53955 | biostudies-arrayexpress
GenomicsThree germline lncRNAs promote PUM protein condensation and germline differentiation
Three germline lncRNAs promote PUM protein condensation and germline differentiation
PRJNA956827 | ENA
TranscriptomicsBudding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [BrdU-ChIP].
Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-22 | E-GEOD-42456 | biostudies-arrayexpress
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