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MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Lipidome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-21 | MTBLS578 | MetaboLights
MetabolomicsThe putative ceramide-conjugation protein Cwh43 regulates G0 quiescence, nutrient metabolism and lipid homeostasis in fission yeast (Metabolome assay)
Cellular nutrient states control whether cells proliferate, or whether they enter or exit quiescence. Here, we report characterizations of fission yeast temperature-sensitive (ts) mutants of the evolutionarily conserved transmembrane protein, Cwh43, and explore its relevance to utilization of glucos...
2018-08-17 | MTBLS577 | MetaboLights
Metabolomics13C-glucose tracing analysis of IFN-treated A549 cells expressing wild-type SARS-CoV-2 Nsp3-4 or a deISGylation-defective Nsp3-4 mutant protein

Interferon (IFN)-stimulated gene 15 (ISG15) regulates diverse cellular processes, including antiviral immunity, through its conjugation to target proteins (ISGylation). Increasing evidence suggests that ISGylation can also reshape cellular metabolism; however, how viruses counteract ISGylation-me...

2026-05-05 | MTBLS14030 | MetaboLights
ProteomicsSite-Selective Protein Conjugation by a Multicomponent Ugi Reaction
The chemical bioconjugation of proteins has seen tremendous applications in the past decades, with the booming of antibody-drug conjugates and their use in oncology. While genetic engineering has permitted to produce bespoke proteins featuring key (un-)natural amino acid residues poised for site-sel...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD045387 | Pride
Biomolecule  site conjugation  chemical biology  peptide mapping 
TranscriptomicssRNA profiling during Oxytricha conjugation
In Oxytricha, the somatic genome is responsible for vegetative growth, while the germline contributes DNA to the next sexual generation. Somatic nuclear development eliminates all transposons and other so-called "junk DNA", which constitute ~95% of the germline. We demonstrate that Piwi-in...
ORGANISM(S): Oxytricha trifallax 
2012-09-01 | E-GEOD-40081 | biostudies-arrayexpress
UnknownDiscriminating changes in protein structure using tyrosine conjugation.
Not available
S-EPMC7380675 | biostudies-literature
ProteomicsE2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation
Posttranslational modifications by ubiquitin-like proteins (UBL) are essential for nearly all cellular processes. Ubiquitin related modifier 1 (Urm1) is a non-canonical UBL which plays a key role in tRNA anticodon thiolation as a sulfur carrier protein (SCP). While Urm1 has also been observed to con...
ORGANISM(S): Chaetomium Thermophilum (ncbitaxon:209285) Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) 
2021-11-16 | MSV000088390 | MassIVE
TranscriptomicsComparative RNA expression analysis of Arabidopsis leaf material differing in genes of SUMO conjugation
SUMO conjugation is an important process in developmental transitions and in environmental stress responses. We generated mutants in the key enzyme SUMO conjugating enzyme 1 of Arabidopsis thaliana and investigated how these mutations affect gene expression in leaves. We also combined mutations in S...
ORGANISM(S): Arabidopsis thaliana 
2026-09-01 | E-MTAB-17503 | biostudies-arrayexpress
TranscriptomicsAnalysis of fetal livers from male mice after protein-restricted diet in mothers
Prenatal nutrition as influenced by nutritional status of the mother has been identified as a determinant of adult disease. Feeding low-protein diets during pregnancy in rodents is a well-established model to induce “programming” events in offspring. We hypothesized that protein restriction would in...
ORGANISM(S): Mus musculus 
2009-11-02 | E-GEOD-15280 | biostudies-arrayexpress
ProteomicsTreatment with Cefotaxime Affects Expression of Conjugation Associated Proteins and Conjugation Transfer Frequency of an IncI1 Plasmid in Escherichia coli
Horizontal gene transfer (HGT) is the major mechanism responsible for spread of antibiotic resistance. Antibiotic treatment has been suggested to promote HGT, either by directly affecting the conjugation process itself or by selecting for conjugations subsequent to DNA transfer. However, recent rese...
ORGANISM(S): Escherichia coli 
2017-11-21 | PXD006679 | Pride
Antibiotics Proteomics Escherichia coli Itraq 
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