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GenomicsBioinformatic analysis of Protein Disulfide Isomerase A1 (PDIA1)-associated pathways towards developing stratified breast cancer therapies
Bioinformatic analysis of Protein Disulfide Isomerase A1 (PDIA1)-associated pathways towards developing stratified breast cancer therapies
PRJNA780603 | ENA
ProteomicsA discovery-based proteomics approach identifies protein disulfide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes
Background: Activation of stress pathways intrinsic to the β cell are thought to both accelerate β cell death and increase β cell immunogenicity in type 1 diabetes (T1D). However, information on the timing and scope of these responses is lacking. Methods: To identify temporal and disease-related c...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035504 | Pride
Proteomics Β cell stress Protein disulfide isomerase a1 Biomarkers Type 1 diabetes 
UnknownCharacterization of an A-Site Selective Protein Disulfide Isomerase A1 Inhibitor.
Not available
S-EPMC5884060 | biostudies-literature
TranscriptomicsBioinformatic analysis of Protein Disulfide Isomerase A1 (PDIA1)-associated pathways towards developing stratified breast cancer therapies
The oxidoreductase protein disulfide isomerase A1 (PDIA1) functions as a cofactor for many transcription factors including the estrogen receptor alpha (ERα), the NF-κΒ, the nuclear factor erythroid 2-like 2 (NRF2) and regulates the protein stability of the tumor suppressor p53. Taking this into acco...
ORGANISM(S): Homo sapiens 
2021-11-18 | GSE188914 | GEO
UnknownProtein-disulfide isomerase displaces the cholera toxin A1 subunit from the holotoxin without unfolding the A1 subunit.
Not available
S-EPMC3121353 | biostudies-literature
UnknownRegulation of perforin lysis: implications for protein disulfide isomerase proteins.
Not available
S-EPMC2667449 | biostudies-literature
UnknownSubstrate-induced unfolding of protein disulfide isomerase displaces the cholera toxin A1 subunit from its holotoxin.
Not available
S-EPMC3916401 | biostudies-literature
UnknownProtein disulfide isomerase A1‑associated pathways in the development of stratified breast cancer therapies.
Not available
S-EPMC8776328 | biostudies-literature
UnknownProtein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis.
Not available
S-EPMC9918675 | biostudies-literature
UnknownRedox signaling-mediated S-glutathionylation of protein disulfide isomerase A1 initiates intrinsic apoptosis and contributes to accelerated aging.
Not available
S-EPMC12172305 | biostudies-literature
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