Sort   by:  
 Page size 
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
MetabolomicsTowards engineering ectomycorrhization into switchgrass bioenergy crops via a lectin receptor-like kinase
Soil-borne microbes can establish compatible relationships with host plants, providing a large variety of nutritive and protective compounds in exchange for photosynthesized sugars. However, the molecular mechanisms mediating the establishment of these beneficial relationships remain unclear. Our pr...
2021-08-11 | MTBLS2597 | MetaboLights
MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
MetabolomicsMetabolomics profiling (GC-MS and LC-MS) for time-course differentiation of pre-B cells-like (B3 cell line) under the controlled induction of the transcription factor Ikaros (STATegra Project)
The main goal of the project is to develop a new generation of bioinformatics resources for the integrative analysis of multiple types of 'omics data. These resources include both novel statistical methodologies as well as user-friendly software implementations. STATegra methods address many aspects...
2016-12-15 | MTBLS283 | MetaboLights
MetabolomicsCell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells

Multicellular organisms such as plants contain various cell types with specialized functions. Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level. Guard cells (GCs) are specialized epid...

2024-09-03 | MTBLS3997 | MetaboLights
MetabolomicsThe ULK3 kinase is a key determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome
Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...
2022-11-14 | MTBLS5155 | MetaboLights
MetabolomicsStress-related mitogen-activated protein kinases stimulate the accumulation of small molecules and proteins in Arabidopsis thaliana root exudates
A delicate balance in cellular signaling is required for plants to distinguish mutualist from parasitic organisms in its environment. Mitogen-activated protein kinase (MAPK) cascades are one of the signaling modules that mediate transduction of extracellular microbial signals into appropriate cellul...
2017-08-25 | MTBLS441 | MetaboLights
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
MetabolomicsImmunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes
The major function of B lymphocytes is to sense antigens and to produce protective antibodies after activation. This function requires the expression of a B-cell antigen receptor (BCR), and evolutionary conserved mechanisms seem to exist that ensure that B cells without a BCR do not develop nor surv...
2020-04-21 | MTBLS186 | MetaboLights
MetabolomicsGDF15 hijacks B cells to fuel the lifeblood of tumor salvage pyrimidine synthesis
B cell-tumor crosstalk has emerged as a critical determinant of tumor progression; however, its role in metabolic reprogramming and therapeutic resistance remains poorly understood. Here, we uncover a metabolic feedback loop that drives resistance to dihydroorotate dehydrogenase (DHODH) inhibitors. ...
2026-09-27 | MTBLS15820 | MetaboLights
Sort   by:  
 Page size