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UnknownAstrocytic deletion of protein kinase R-like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke.
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S-EPMC10524975 | biostudies-literature
TranscriptomicsPrognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [gene expression]
Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells ...
ORGANISM(S): Homo sapiens 
2015-11-21 | E-GEOD-64256 | biostudies-arrayexpress
TranscriptomicsPrognostic significance of overexpression of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer [copy number analysis]
Introduction: The potential of expression profiling using microarray analysis as a tool to predict the prognosis for different types of cancer has been realized. This study aimed to identify a novel biomarker for colorectal cancer (CRC). Experimental design: The expression profiles of cancer cells ...
ORGANISM(S): Homo sapiens 
2015-11-21 | E-GEOD-64257 | biostudies-arrayexpress
TranscriptomicsUnderstanding the role of Shoc2 protein in spatio-temporal regulation of extracellular signal-regulated kinase (ERK1/2) cascade
This study was designed to understanding changes in RNA transcription in cells depleted of Shoc2 scaffold. 2 samples were analyzed (3 replicates for each sample were included). Cos1 is a control sample.
ORGANISM(S): Chlorocebus sabaeus 
2016-01-15 | E-GEOD-67063 | biostudies-arrayexpress
Transcriptomicsc-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells [MCF-7:5C]
The emergence of anti-estrogen resistance in breast cancer is an important clinical phenomenon affecting long-term survival in this disease. Identifying factors that convey cell survival in this setting may guide improvements in treatment. Estrogen (E2) can induce apoptosis in breast cancer cells th...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-59535 | biostudies-arrayexpress
TranscriptomicsIntegrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.
Abstract BACKGROUND: The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling...
ORGANISM(S): Homo sapiens 
2016-08-21 | E-GEOD-74667 | biostudies-arrayexpress
TranscriptomicsNeurons shift translational control to secure proteostatic resilience during ER stress
Proteostasis is essential for survival and particularly important for highly specialized post mitotic cells like neurons. Transient reduction of protein synthesis by protein kinase R–like endoplasmic reticulum (ER) kinase (PERK)-mediated phosphorylation of eukaryotic translation initiation factor 2α...
ORGANISM(S): Mus musculus 
2022-06-13 | GSE200742 | GEO
TranscriptomicsTranscription profiling of MCF-7 cell lines stably overexpressing constitutively active Raf-1, constitutively active MEK, constitutively active c-erbB-2, or ligand-activatable EGFR as models of overexpressed growth factor signaling
Profiling of MCF-7 cell lines stably overexpressing constitutively active Raf-1, constitutively active MEK, constitutively active c-erbB-2, or ligand-activatable EGFR as models of overexpressed growth factor signaling, as well as control vector transfected cells (coMCF-7) and control vector transfec...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-3542 | biostudies-arrayexpress
GenomicsGenome wide extracellular signal-regulated kinase (ERK) pathway components interaction with human genome
Several recent studies, including ours, show that most components of signal transduction cascades including the extracellular signal-regulated protein kinase (ERK), that once were thought to act predominantly in cytoplasm, are in fact recruited to chromatin and are integral components of transcript...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-65323 | biostudies-arrayexpress
TranscriptomicsSevere acute respiratory syndrome coronavirus envelope protein regulates cell stress responses and apoptosis
Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo [1,2]. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected by SARS-CoV with or without E gene was compared. Twenty-five stress respo...
ORGANISM(S): Chlorocebus aethiops 
2012-06-20 | E-GEOD-30589 | biostudies-arrayexpress
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