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ProteomicsIntegrating Protein Language Models and Automatic Biofoundry for Enhanced Protein Evolution
Traditional protein engineering methods, such as directed evolution, while effective, are often slow and labor-intensive. Advances in machine learning and automated biofoundry present new opportunities for optimizing these processes. This study devises a protein language model-enabled automatic evol...
ORGANISM(S): Escherichia coli 
2024-12-25 | PXD058768 | Pride
Protein language models Protein engineering Directed evolution Automatic biofoundry 
MetabolomicsThe Impact of Ethnicity and Intra-Pancreatic Fat on the Postprandial Metabolome Response to Whey Protein in Overweight Asian Chinese and European Caucasian Women with Prediabetes
The 'Thin on the Outside Fat on the Inside' TOFI_Asia study found Asian Chinese to be more susceptible to Type 2 Diabetes (T2D) compared to European Caucasians matched for gender and body mass index (BMI). This was influenced by degree of visceral adipose deposition and ectopic fat accumulation in k...
2022-10-12 | MTBLS5568 | MetaboLights
TranscriptomicsProtein language models-assisted optimization of a Uracil-N glycosylase variant enables programmable T-to-S base editing
Current base editors use DNA deaminases, including cytidine deaminase in cytidine base editor (CBE) or adenine deaminase in adenine base editor (ABE), to facilitate transition nucleotide substitutions. Combining CBE or ABE with glycosylase enzymes can induce limited transversion mutations. Nonethele...
ORGANISM(S): Homo sapiens 
2024-01-23 | GSE253655 | GEO
UnknownDeepLoc 2.0: multi-label subcellular localization prediction using protein language models.
Not available
S-EPMC9252801 | biostudies-literature
Genomicssynthetic construct
Customizing CRISPR-Cas PAM specificity with protein language models
PRJNA1378997 | ENA
UnknownCollectively encoding protein properties enriches protein language models.
Not available
S-EPMC9641823 | biostudies-literature
UnknownBiophysics-based protein language models for protein engineering.
Not available
S-EPMC10980077 | biostudies-literature
UnknownBiophysics-based protein language models for protein engineering.
Not available
S-EPMC12446067 | biostudies-literature
UnknownHaloClass: Salt-Tolerant Protein Classification with Protein Language Models.
Not available
S-EPMC11543744 | biostudies-literature
UnknownBepiPred-3.0: Improved B-cell epitope prediction using protein language models.
Not available
S-EPMC9679979 | biostudies-literature
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