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MetabolomicsM3-Driven Hexosamine Biosynthesis Facilitates Hepatocellular Carcinoma Progression through YBX1 O-GlcNAcylation
Phosphoglucomutase 3 (PGM3) is one of the rate-limiting enzymes in the hexosamine biosynthesis pathway (HBP) and a key regulator of HBP metabolic flux. Despite the functional role of PGM3 has been validated in various tumors, its function and molecular mechanism in hepatocellular carcinoma (HCC) rem...
2026-09-04 | MTBLS15552 | MetaboLights
MetabolomicsPGM3-Driven Hexosamine Biosynthesis Facilitates Hepatocellular Carcinoma Progression through YBX1 O-GlcNAcylation (Untargeted metabolomics)
Phosphoglucomutase 3 (PGM3) is one of the rate-limiting enzymes in the hexosamine biosynthesis pathway (HBP) and a key regulator of HBP metabolic flux. Despite the functional role of PGM3 has been validated in various tumors, its function and molecular mechanism in hepatocellular carcinoma (HCC) rem...
2026-09-03 | MTBLS15545 | MetaboLights
TranscriptomicsDrosophila Oga deletion perturbs O-GlcNAcylation of chromatin factors
Drosophila development is a complex and dynamic process regulated, in part, by members of the Polycomb (Pc), Trithorax (Trx) and Compass chromatin modifier complexes. O-GlcNAc Transferase (OGT/SXC) is essential for Pc repression suggesting that the O-GlcNAcylation of proteins plays a key role in re...
ORGANISM(S): Drosophila melanogaster 
2016-07-21 | E-GEOD-74846 | biostudies-arrayexpress
MetabolomicsGNPS - A novel quantitative mass spectrometry platform for determining site-specific protein O-GlcNAcylation dynamics
Over the past decades, protein O-GlcNAcylation has been found to play a fundamental role in cell cycle control, metabolism, transcriptional regulation, and cellular signaling. Nevertheless, quantitative approaches to determine in vivo GlcNAc dynamics at a large-scale are still not readily available....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080705 | GNPS
ProteomicsSystematic Quantification of Protein O-GlcNAcylation Reveals Common and Cell-Type-Specific Responses to N-Glycosylation Inhibition in Human Cells
In this work, we systematically and site-specifically analyzed protein O-GlcNAcylation under the N-glycosylation inhibition through the integration of metabolic labeling, bio-orthogonal chemistry, and multiplexed proteomics. The experiments were performed in three types of human cells, i.e., HEK293T...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD073249 | Pride
Glycoproteomics Protein o-glcnacylation 
ProteomicsImmunoprecipitation of YAP - The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
YAP was immunoprecipitated to detect O-GlcNAcylation status.
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005992 | Pride
Liver yap o-glcnacylation 
ProteomicsA novel quantitative mass spectrometry platform for determining site-specific protein O-GlcNAcylation dynamics
Over the past decades, protein O-GlcNAcylation has been found to play a fundamental role in cell cycle control, metabolism, transcriptional regulation, and cellular signaling. Nevertheless, quantitative approaches to determine in vivo GlcNAc dynamics at a large-scale are still not readily available....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080705 | MassIVE
ProteomicsO-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling
Ligand-stimulated epidermal growth factor receptor (EGFR) signaling plays fundamental roles in normal cell physiology, such as cell growth, cell proliferation, and cell survival. Deregulation of EGFR signaling contributes to the development and progression of diseases including cancer. Despite its e...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD031700 | Pride
Endosomal sorting Membrane receptors O-glcnacylation Egfr 
ProteomicsImmunoprecipitation of YAP - Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy
YAP was immunoprecipitated to detect O-GlcNAcylation status.
ORGANISM(S): Homo sapiens (Human) 
2024-10-27 | PXD056603 | Pride
Hippo signaling， o-glcnacylation 
ProteomicsA novel quantitative mass spectrometry platform for determining site-specific protein O-GlcNAcylation dynamics
Over the past decades, protein O-GlcNAcylation has been found to play a fundamental role in cell cycle control, metabolism, transcriptional regulation, and cellular signaling. Nevertheless, quantitative approaches to determine in vivo GlcNAc dynamics at a large-scale are still not readily available....
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD002591 | Pride
Mass spectrometry method determines protein o-glcnacylation rates 
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