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MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
MetabolomicsB-cell Translocation Gene 2 Inhibits UFMylation Modification of FMO1 thus Restricting Taurine Synthesis and Exacerbating Ferroptosis in Hepatic Ischemia-Reperfusion Injury

Hepatic ischemia-reperfusion (I/R) injury is a common complication occurs during liver transplantation. However, the mechanisms underlying hepatic I/R injury have not been fully elucidated. B-cell translocation gene 2 (Btg2) has been implicated in the development of various diseases. However, its...

2026-03-07 | MTBLS11677 | MetaboLights
TranscriptomicsGeneration of NPM1-ALK translocation in human T lymphocytes faithfully recapitulates the diversity of ALK+ ALCL tumor phenotype
To recapitulate the t(2;5)(p23;q35) chromosomal translocation, activated T lymphocytes from healthy donors PBMC were transfected with the RNP complex composed of the protein Cas9 with gRNA NPM1 (targeting NPM1 gene) and gRNA ALK (targeting ALK gene). Control cells were wild-type CD4+ activated lymp...
ORGANISM(S): Homo sapiens 
2022-02-09 | E-MTAB-10924 | biostudies-arrayexpress
GenomicsStress modulates Ahi1-dependent nuclear localization of Ten-Eleven Translocation Protein 2
Stress modulates Ahi1-dependent nuclear localization of Ten-Eleven Translocation Protein 2
PRJNA704360 | ENA
ProteomicsEscherichia coli can adapt its protein translocation machinery for enhanced periplasmic recombinant protein production
Recently, we engineered a tunable rhamnose promoter-based setup for the production of recombinant proteins in E. coli. This setup enabled us to show that being able to precisely set the production rate of a secretory recombinant protein is critical to enhance protein production yields in the peripla...
ORGANISM(S): Escherichia coli 
2020-03-05 | PXD013168 | Pride
E.coli Recombinant protein production Protein secretion 
TranscriptomicsDifferential Expression of NF-kB target genes in MALT lymphoma with and without chromosome translocation
MALT lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the NF-κB pathway. Gastric MALT lymphomas harboring such translocation do not respond to H. pylori eradication, while those without translocation can be...
ORGANISM(S): Homo sapiens 
2010-05-31 | E-GEOD-18736 | biostudies-arrayexpress
Genomicsα-Synuclein blocks endoplasmic reticulum protein translocation in Parkinson’s disease [scRNA-seq]
α-Synuclein blocks endoplasmic reticulum protein translocation in Parkinson’s disease [scRNA-seq]
PRJNA1157842 | ENA
ProteomicsA proteomic study on the membrane protein fraction of T cells confirms high substrate selectivity for the ER translocation inhibitor cyclotriazadisulfonamide
Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of type I integral membrane protein human CD4 (huCD4) across the ER in a signal peptide (SP)-dependent way. Previously, sortilin was identified as a secondary substrate for CADA but showed reduced CADA sensitivity as compare...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD027712 | Pride
Cd4  cyclotriazadisulfonamide (cada)  er co-translational translocation  signal peptide  silac 
GenomicsSAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum
PRJNA917767 | ENA
Genomicsα-Synuclein blocks endoplasmic reticulum protein translocation in Parkinson’s disease [bulk RNA-seq]
α-Synuclein blocks endoplasmic reticulum protein translocation in Parkinson’s disease [bulk RNA-seq]
PRJNA1156797 | ENA
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