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ProteomicsEpithelial ovarian cancer biomarker
Protein biomarkers of early stages of disease are critical for managing the disease and improving outcomes. Unfortunately, discovery of protein biomarkers is hampered by the limited availability of assays for sensitive and reproducible quantification of proteins in complex biological matrices such a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-02 | MSV000084048 | MassIVE
ProteomicsIdentification of novel biomarker candidates for the immunohistochemical diagnosis of cholangiocellular carcinoma - LC-MS Part
The aim of this study was the identification of biomarkers for the immunohistochemical diagnosis of cholangiocellular carcinoma (CCC). CCC is a primary cancer which arises from the epithelial cells of the bile ducts and is characterised by high mortality rates due to its late clinical presentation a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082885 | MassIVE
ProteomicsIdentification of bone marrow and peripheral blood plasma extracellular vesicle protein biomarker signatures for multiple myeloma diagnosis and staging
Multiple myeloma (MM) is a hematological malignancy characterised by the clonal proliferation of abnormal plasma cells within the bone marrow (BM). Despite advances in treatment that have improved survival, the disease remains incurable. MM diagnosis requires invasive bone marrow biopsy to quantify ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD069556 | Pride
Machine learning Cancer Multiple myeloma Extracellular vesicles Biomarker signature Proteomic 
UnknownMass spectrometry based biomarker discovery, verification, and validation--quality assurance and control of protein biomarker assays.
Not available
S-EPMC5528535 | biostudies-literature
ProteomicsDeep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disease, the most common cause of dementia in elderly persons. Accumulation of amyloid plaques in the brain is a characteristic of AD. The requirements for a biomarker include the ability to measure a pathologic process, predict outcome, distinguish di...
ORGANISM(S): Homo sapiens (Human) 
2019-04-23 | PXD011482 | Pride
Proteomics Alzheimer’s disease Human blood Mass spectrometry Plasma Serum Proteome Tandem mass tag Biomarker 
ProteomicsPlasma proteome profiling to detect and avoid sample-related biases in biomarker studies
Blood-based protein tests inform medical decision-making, but despite major investments, few new biomarkers reach the clinic. Plasma and serum are rich sources of information about an individual’s health state and mass spectrometry (MS)-based proteomics now allows highly specific and quantitative re...
ORGANISM(S): Homo sapiens (Human) 
2018-11-23 | PXD011749 | Pride
Plasma Quality Pre-analytics Biomarker Plasma proteome profiling 
UnknownSequential Validation of Blood-Based Protein Biomarker Candidates for Early-Stage Pancreatic Cancer.
Not available
S-EPMC5441297 | biostudies-literature
ProteomicsThromboxane-A Synthase 1 as a Potential Dual Biomarker for Metastatic Prostate Cancer and Atherosclerosis: Insights from a Nanomedicine Protein Corona, Machine Learning, and Actual Causality Approaches
Prostate cancer (PC) is the most common cancer among men in the United States, while atherosclerosis (ASCVD) is the most prevalent cardiovascular disease (CVD) associated with it. CVD, particularly ASCVD, has been shown to contribute to metastatic prostate cancer (mPC) progression. Identifying blood...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD057863 | Pride
Protein corona Bottom up proteomics Machin learning Human plasma 
ProteomicsConcentration determination of >200 proteins in dried blood spots for biomarker discovery and validation
Raw files were created using XCalibur 3.0.63 (Thermo Scientific) software and analysed with Thermo Proteome Discoverer 2.2.0.388 software suite (Thermo Scientific). The raw data files were processed as previously described 26 with the following modifications: the peak lists were submitted to Mascot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-11-27 | MSV000084629 | MassIVE
ProteomicsA new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model (validation part)
To-date, most proteomic studies aimed at discovering tissue-based cancer biomarkers have compared the quantity of selected proteins between case and control groups. However, proteins generally function in association with other proteins to form modules localized in particular subcellular compartment...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD013295 | Pride
Mouse Cancer Biomarker Liver 
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