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MetabolomicsThermal Profiling Maps Multilayered Organization of the Mitochondrial Proteome

Mitochondria execute essential metabolic, biosynthetic, and signaling functions, yet the regulatory principles governing their proteome remain incompletely understood. Here, we develop a thermal proteome profiling (TPP) workflow applied directly to purified mitochondria, enabling systematic analy...

2025-12-08 | MTBLS7386 | MetaboLights
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Metabolite profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9830 | MetaboLights
MetabolomicsNew plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K
Plasma untargeted metabolomics is a common method for evaluation of the mechanisms underlying human pathologies and identification of novel biomarkers. The plasma proteins provide the environment for transport of hydrophobic metabolites. The current sample preparation protocol relies on the immediat...
2022-03-18 | MTBLS670 | MetaboLights
TranscriptomicsRNA-seq of A431 cell line after gefitinib treatment
RNA sequencing of A431 cell line samples before and after gefitinib treatment, at 0, 2, 6 and 24 hours, was performed in order to characterize the cell line's early and late response to this drug, and to compare against proteomics (mass spectrometry) characterization of the cell line using the same ...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5285 | biostudies-arrayexpress
UnknownProteome Coverage after Simultaneous Proteo-Metabolome Liquid-Liquid Extraction.
Not available
S-EPMC9990123 | biostudies-literature
ProteomicsDrosophila melanogaster proteome dataset with high coverage of the genome based on the LC-MS/MS platform
Here we describe a high coverage dataset of whole fly through a one-dimensional gel electrophoresis LC-MS/MS approach. By combining the datasets of two kinds of SDS-PAGE and two kinds of tagmata, the high coverage analysis resulted in the identification of 5,262 genes, corresponding to 38.23% of the...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2013-11-27 | PXD000455 | Pride
High coverage Proteome Lc-ms/ms 
UnknownExpanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis.
Not available
S-EPMC5363888 | biostudies-literature
UnknownImproved proteome coverage by using iTRAQ labelling and peptide OFFGEL fractionation.
Not available
S-EPMC2572582 | biostudies-literature
UnknownHuman fallopian tube proteome shows high coverage of mesenchymal stem cells associated proteins.
Not available
S-EPMC4759609 | biostudies-literature
TranscriptomicsA proteomic view on the cell biology of Staphylococcus aureus proteome
The genome sequence is the “blue-print of life”, but proteomics is required to relate this blue-print of life to the actual physiology of living cells. Because of their low complexity – only about 2.000 proteins make a Staphylococcus aureus cell viable – bacteria are excellent model systems to ident...
ORGANISM(S): Staphylococcus aureus 
2009-11-11 | E-GEOD-15060 | biostudies-arrayexpress
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